Listar por autor "Schmitt, Gertrud"
Mostrando ítems 1-8 de 8
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Effective remodelling of human osteoarthritic cartilage by sox9 gene transfer and overexpression upon delivery of rAAV vectors in polymeric micelles
Rey-Rico, Ana; Venkatesan, Jagadesh K.; Schmitt, Gertrud; Speicher-Mentges, Susanne; Madry, Henning; Cucchiarini, Magali (American Chemical Society, 2018-05-15)[Abstract] Recombinant adeno-associated virus (rAAV) vectors are well suited carriers to provide durable treatments for human osteoarthritis (OA). Controlled release of rAAV from polymeric micelles was already shown to ... -
Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
Daniels, Oliver; Rey-Rico, Ana; Schmitt, Gertrud; Venkatesan, Jagadeesh Kumar; Cucchiarini, Magali; Frisch, Janina (MDPI, 2019)[Abstract] Gene therapy for osteoarthritis offers powerful, long-lasting tools that are well adapted to treat such a slow, progressive disorder, especially those therapies based on the clinically adapted recombinant ... -
Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Schmitt, Gertrud; Speicher-Mentges, Susanne; Falentin-Daudré, Céline; Leroux, Amélie; Madry, Henning; Migonney, Véronique; Cucchiarini, Magali (MDPI, 2020)[Abstract] Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
Rey-Rico, Ana; Madry, Henning; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cai, Xiaoyu; Meng, Weikun; Cucchiarini, Magali; Maihöfer, Johanna; Goebel, Lars; Zurakowski, David; Menger, Michael D.; Laschke, Matthias W. (Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
Meng, Weikun; Rey-Rico, Ana; Claudel, Mickaël; Schmitt, Gertrud; Speicher-Mentges, Susanne; Pons, Françoise; Lebeau, Luc; Venkatesan, Jagadeesh K.; Cucchiarini, Magali (MDPI, 2020-04-28)[Abstract] Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility ... -
Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells
Morscheid, Stephanie; Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Schmitt, Gertrud; Cucchiarini, Magali (MDPI, 2019-08-28)[Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ... -
Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells
Morscheid, Stephanie; Rey-Rico, Ana; Schmitt, Gertrud; Madry, Henning; Cucchiarini, Magali; Venkatesan, Jagadeesh Kumar (MDPI, 2019-05-27)[Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
Madry, Henning; Rey-Rico, Ana; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cucchiarini, Magali; Goebel, Lars; Zurakowski, David; Laschke, Matthias W.; Cai, Xiaoyu; Menger, Michael D.; Gao, Liang; Müller-Brandt, Kathrin (WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...