Listar por autor "Sautet, Alain"
Mostrando ítems 1-2 de 2
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Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis
Trellu, Sabine; Courties, Alice; Jaisson, Stéphane; Gorisse, Laëtitia; Gillery, Philippe; Kerdine-Römer, Saadia; Vaamonde-García, Carlos; Houard, Xavier; Ekhirch, François-Paul; Sautet, Alain; Friguet, Bertrand; Jacques, Claire; Berenbaum, Francis; Sellam, Jérémie (Springer Nature, 2019-01-11)[Abstract] Background: Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially ... -
The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis
Vaamonde-García, Carlos; Courties, Alice; Pigenet, Audrey; Laiguillon, Marie-Charlotte; Sautet, Alain; Houard, Xavier; Kerdine-Römer, Saadia; Meijide-Faílde, Rosa; Berenbaum, Francis; Sellam, Jérémie (American Society for Biochemistry and Molecular Biology, 2017-07-06)[Asbtract] Epidemiological findings support the hypothesis that type 2 diabetes mellitus (T2DM) is a risk factor for osteoarthritis (OA). Moreover, OA cartilage from patients with T2DM exhibits a greater response to ...