Listar por autor "Pazos, Elena"

Mostrando ítems 1-10 de 10

    • A Bio-inspired Hypoxia Sensor using HIF1a-Oxygen-Dependent Degradation Domain 

      Iglesias, Pablo; Penas, Cristina; Barral-Cagiao, Laura; Pazos, Elena; Costoya, Jose A. (Nature, 2019-05-08)
      [Abstract] Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural ...

    • Affinity-Controlled Capture and Release of Engineered Monoclonal Antibodies by Macroporous Dextran Hydrogels Using Coiled-Coil Interactions [Report] 

      Baniahmad, Seyed Farzad; Oliverio, Romane; Obregón Gómez, Inés; Robert, Alma; Lenferink, Anne; Pazos, Elena; Virgilio, Nick; Banquy, Xavier; De Crescenzo, Gregory; Durocher, Yves (Taylor & Francis, 2023-06-10)
      [Abstract] Long-term delivery is a successful strategy used to reduce the adverse effects of monoclonal antibody (mAb)-based treatments. Macroporous hydrogels and affinity-based strategies have shown promising results in ...

    • Amino Acid–Viologen Hybrids: Synthesis, Cucurbituril Host–Guest Chemistry, and Implementation on the Production of Peptides 

      Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (American Chemical Society, 2021-12-10)
      [Abstract] We present herein the development of a series of viologen–amino acid hybrids, obtained in good yields either by successive alkylations of 4,4′-bipyridine, or by Zincke reactions followed by a second alkylation ...

    • Controlled Binding of Organic Guests by Stimuli-Responsive Macrocycles 

      Blanco-Gómez, Arturo; Cortón, Pablo; Barravecchia Prado, Liliana Inés; Neira, Iago; Pazos, Elena; Peinador, Carlos; García, Marcos D. (Royal Society of Chemistry, 2020-05-12)
      [Abstract] Synthetic supramolecular chemistry pursues not only the construction of new matter, but also control over its inherently dynamic behaviour. In this context, classic host–guest chemistry, based on the development ...

    • Cucurbit[8]uril (CB[8])-Based Supramolecular Switches 

      Pazos, Elena; Novo, Paula; Peinador, Carlos; Kaifer, Angel; García, Marcos D. (Wiley, 2018-07-06)
      [Abstract] The use of cucurbit[8]uril as a molecular host has emerged in the chemical literature as a reliable strategy for the creation of dynamic chemical systems, owing to its ability to form homo- and heteroternary ...

    • Probing Tyrosine Nitration with a Small TbIII-Metallopeptide 

      Sánchez-Fernández, Rosalía; Sánchez-Temprano, Agustín; Esteban-Gómez, David; Pazos, Elena (Wiley, 2023-06-06)
      [Abstract] Tyrosine nitration, a post-translational modification (PTM) that takes place under nitrosative stress conditions, occurs through a non-enzymatic peroxynitrite-mediated reaction. Although protein nitration has ...

    • Reversible Control of DNA Binding with Cucurbit[8]uril-Induced Supramolecular 4,4′-Bipyridinium–Peptide Dimers 

      Novo, Paula; García, Marcos D.; Peinador, Carlos; Pazos, Elena (American Chemical Society, 2021-03-08)
      [Abstract] Many cellular processes in living organisms are regulated by complex regulatory networks, built from noncovalent interactions between relatively few proteins that perform their functions by switching between ...

    • Self-Assembled Peptide–Inorganic Nanoparticle Superstructures: From Component Design to Applications 

      Pigliacelli, Claudia; Sánchez-Fernández, Rosalía; García, Marcos D.; Peinador, Carlos; Pazos, Elena (Royal Society of Chemistry, 2020-06-04)
      [Abstract] Peptides have become excellent platforms for the design of peptide–nanoparticle hybrid superstructures, owing to their self-assembly and binding/recognition capabilities. Morover, peptide sequences can be encoded ...

    • Site-Selective C–H Amination of Phenol-Containing Biomolecules 

      Girón-Elola, Carlota; Sasiain, Ibon; Sánchez-Fernández, Rosalía; Pazos, Elena; Correa, Arkaitz (American Chemical Society, 2023-06-07)
      [Abstract] A C–N bond-forming cross-dehydrogenative coupling of a collection of Tyr-containing peptides and estrogens with heteroarenes is described. This oxidative coupling is distinguished by its scalability, operational ...

    • The Red Cage: Implementation of pH-Responsiveness Within a Macrobicyclic Pyridinium-Based Molecular Host 

      Cortón, Pablo; Wang, Hongye; Neira, Iago; Blanco-Gómez, Arturo; Pazos, Elena; Peinador, Carlos; Li, Hao; García, Marcos D. (Royal Society of Chemistry, 2021-11-09)
      [Abstract] We present herein the implementation of pH-responsiveness into a new polycationic macrobicyclic structure, namely what we have termed the “red cage”. The hydrolytically-stable cryptand-like compound has been ...