Listar por autor "Pájaro Diéguez, Manuel"
Mostrando ítems 1-7 de 7
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Feedback control of stochastic gene switches using PIDE models
Fernández, Christian; Faquir, Hamza; Pájaro Diéguez, Manuel; Otero-Muras, Irene (Elsevier, 2022)[Abstract]: Achieving control of gene regulatory circuits is one of the goals of synthetic biology, as a way to regulate cellular functions for useful purposes (in biomedical, environmental or industrial applications). The ... -
First passage times as a measure of hysteresis in stochastic gene regulatory circuits
Pájaro Diéguez, Manuel; Otero-Muras, Irene; Alonso, Antonio A. (Elsevier, 2022)[Abstract]: In the context of phenotype switching and cell fate determination, numerousexperimental studies report hysteresis, despite the fact that the (forward) Chemical Master Equation governing the inherently stochastic ... -
IDESS: a toolbox for identification and automated design of stochastic gene circuits
Sequeiros Ferreiro, Carlos Xosé; Pájaro Diéguez, Manuel; Vázquez, Carlos; Banga, Julio R.; Otero-Muras, Irene (Oxford University Press, 2023-11)[Abstract]: Motivation One of the main causes hampering predictability during the model identification and automated design of gene circuits in synthetic biology is the effect of molecular noise. Stochasticity may ... -
SELANSI: A toolbox for simulation of stochastic gene regulatory networks
Pájaro Diéguez, Manuel; Otero-Muras, Irene; Vázquez, Carlos; Alonso, Antonio (Oxford University Press, 2018-03)[Abstract]: Motivation Gene regulation is inherently stochastic. In many applications concerning Systems and Synthetic Biology such as the reverse engineering and the de novo design of genetic circuits, stochastic effects ... -
Stochastic SIR model predicts the evolution of COVID-19 epidemics from public health and wastewater data in small and medium-sized municipalities: A one year study
Pájaro Diéguez, Manuel; Fajar, Noelia M; Alonso, Antonio; Otero-Muras, Irene (Elsevier, 2022-11)[Abstract]: The level of unpredictability of the COVID-19 pandemics poses a challenge to effectively model its dynamic evolution. In this study we incorporate the inherent stochasticity of the SARS-CoV-2 virus spread by ... -
Transient hysteresis and inherent stochasticity in gene regulatory networks
Pájaro Diéguez, Manuel; Otero-Muras, Irene; Vázquez, Carlos; Alonso, Antonio (Nature Publishing Group, 2019-10-08)[Abstract] Cell fate determination, the process through which cells commit to differentiated states is commonly mediated by gene regulatory motifs with mutually exclusive expression states. The classical deterministic ... -
Wastewater and marine bioindicators surveillance to anticipate COVID-19 prevalence and to explore SARS-CoV-2 diversity by next generation sequencing: One-year study
Novoa, Beatriz; Ríos-Castro, Raquel; Otero-Muras, Irene; Gouveia, Susana; Cabo, Adrián; Saco, Amaro; Rey-Campos, Magalí; Pájaro Diéguez, Manuel; Fajar, Noelia M; Aranguren, Raquel; Romero, Alejandro; Panebianco, Antonella; Valdés, Lorena; Payo, Pedro; Alonso, Antonio; Figueras, Antonio; Cameselle, Claudio (Elsevier, 2022)[Abstract] This study presents the results of SARS-CoV-2 surveillance in sewage water of 11 municipalities and marine bioindicators in Galicia (NW of Spain) from May 2020 to May 2021. An integrated pipeline was developed ...