• AGT haplotype in ITGA4 gene is related to antibody-mediated rejection in heart transplant patients 

      Núñez, Lucía; Marrón Liñares, Grecia Manuela; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Álvarez López, Eloy; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Pombo-Otero, Jorge; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel (Stanislaw Stepkowski,, 2019-07-23)
      [Abstract] Introduction. One of the main problems involved in heart transplantation (HT) is antibody-mediated rejection (AMR). Many aspects of AMR are still unresolved, including its etiology, diagnosis and treatment. ...
    • Analysis of the association between copy number variation and ventricular fibrillation in ST-elevation acute myocardial infarction 

      Lorente-Bermúdez, Roberto; Pan-Lizcano, Ricardo; Núñez, Lucía; López-Vázquez, Domingo; Rebollal-Leal, Fernando; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel (MDPI, 2024-02-22)
      [Abstract] Sudden cardiac death due to ventricular fibrillation (VF) during ST-elevation acute myocardial infarction (STEAMI) significantly contributes to cardiovascular-related deaths. Although VF has been linked to genetic ...
    • Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report 

      Núñez, Lucía; Crespo-Leiro, María Generosa; Marrón Liñares, Grecia Manuela; Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Muñiz, Javier; Vázquez Rodríguez, José Manuel; Hermida-Prieto, Manuel (Via Médica, 2016)
      [Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction ...
    • Circulating miR-181a-5p as a New Biomarker for Acute Cellular Rejection in Heart Transplantation 

      Constanso-Conde, Ignacio; Hermida-Prieto, Manuel; Barge-Caballero, Eduardo; Núñez, Lucía; Pombo-Otero, Jorge; Suárez-Fuentetaja, Natalia; Paniagua-Martín, María J.; Barge-Caballero, Gonzalo; Couto-Mallón, David; Pan Lizcano, Ricardo Francisco; Vázquez Rodríguez, José Manuel; Crespo-Leiro, María Generosa (Elsevier, 2020-06-07)
      [Abstract] Background: Acute cellular rejection (ACR) is a major complication in heart transplantation (HTx). Endomyocardial biopsy is the reference method for early detection of ACR, but a new non-invasive approach is ...
    • lncRNA CDKN2B-AS1 is downregulated in patients with ventricular fibrillation in acute myocardial infarction 

      Pan-Lizcano, Ricardo; Núñez, Lucía; Piñón-Esteban, Pablo; Aldama-López, Guillermo; Flores-Ríos, Xacobe; Calviño-Santos, Ramón; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel (PLoS One, 2024-05-21)
      [Abstract] Ventricular fibrillation (VF) in acute myocardial infarction (AMI) is the main cause of deaths occurring in the acute phase of an ischemic event. Although it is known that genetics may play an important role in ...
    • Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection 

      Marrón Liñares, Grecia Manuela; Núñez, Lucía; Crespo-Leiro, María Generosa; Barge-Caballero, Eduardo; Pombo-Otero, Jorge; Paniagua-Martín, María J.; Suárez-Fuentetaja, Natalia; Cid, Javier; Grille Cancela, Zulaika; Muñiz, Javier; Tan, Carmela D.; Rene Rodríguez, E.; Vázquez Rodríguez, José Manuel; Hermida-Prieto, Manuel (Elsevier, 2017-07-15)
      [Abstract] Background. Heart transplantation (HT) is a life-saving treatment for patients with end-stage heart failure. One of the main problems after HT is the humoral response termed antibody-mediated rejection (AMR). ...
    • Presence of Bacterial DNA in Thrombotic Material of Patients with Myocardial Infarction 

      Piñón-Esteban, Pablo; Núñez, Lucía; Moure, Raquel; Marrón Liñares, Grecia Manuela; Flores Ríos, Xacobe; Aldama López, Guillermo; Salgado-Fernández, Jorge; Calviño-Santos, Ramón; Rebollal-Leal, Fernando; Pan Lizcano, Ricardo Francisco; Vázquez-González, Nicolás; Bou, Germán; Tomás, María; Hermida-Prieto, Manuel; Vázquez Rodríguez, José Manuel (Nature Publishing Group, 2020-10-01)
      [Abstract] Infectious agents have been suggested to be involved in etiopathogenesis of Acute Coronary Syndrome (ACS). However, the relationship between bacterial infection and acute myocardial infarction (AMI) has not yet ...
    • Rare variants in genes of the cholesterol pathway are present in 60% of patients with acute myocardial infarction 

      Pan-Lizcano, Ricardo; Mariñas-Pardo, Luis; Núñez, Lucía; Rebollal-Leal, Fernando; López-Vázquez, Domingo; Pereira, Ana; Molina-Nieto, Aránzazu; Calviño, Ramón; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel (MDPI, 2022-12-17)
      [Abstract] Acute myocardial infarction (AMI) is a pandemic in which conventional risk factors are inadequate to detect who is at risk early in the asymptomatic stage. Although gene variants in genes related to cholesterol, ...
    • Screening Mutations in Myosin Binding Protein C3 Gene in a Cohort of Patients With Hypertrophic Cardiomyopathy 

      Rodríguez García, María Isabel; Monserrat, Lorenzo; Ortiz, Martín; Fernández, Xusto; Cazón, Laura; Núñez, Lucía; Barriales-Villa, Roberto; Maneiro, Emilia; Veira, Elena; Castro-Beiras, Alfonso; Hermida-Prieto, Manuel (BioMed Central, 2010)
      [Abstract] Background. MyBPC3 mutations are amongst the most frequent causes of hypertrophic cardiomyopathy, however, its prevalence varies between populations. They have been associated with mild and late onset disease ...