Listar por autor "Morente-López, Miriam"
Mostrando ítems 1-6 de 6
-
Effect of aging on behaviour of mesenchymal stem cells
Fafián Labora, Juan Antonio; Morente-López, Miriam; Arufe, M.C. (Baishideng Publishing Group Inc., 2019-06-26)[Abstract] Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult ... -
Effect of miR-21 in mesenchymal stem cells-derived extracellular vesicles behavior
Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Gil, Concha; Carrera, Mónica; Fafián Labora, Juan Antonio; Arufe, M.C. (BioMed Central, 2023-12-21)[Abstract] Background: A challenging new branch of research related to aging-associated diseases is the identification of miRNAs capable of modulating the senescence-associated secretory phenotype (SASP) which characterizes ... -
Influence of mesenchymal stem cell-derived extracellular vesicles in vitro and their tole in ageing
Fafián Labora, Juan Antonio; Morente-López, Miriam; Sánchez-Dopico, María José; Arntz, O.J.; Van de Loo, F.J.; De-Toro, Javier; Arufe, M.C. (Springer Nature, 2020-01-03)[Abstract] Introduction: This study assessed whether mesenchymal stem cell (MSC)-derived extracellular vesicles influenced ageing and pluripotency markers in cell cultures where they are added. Methods: MSC-derived ... -
Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging
Mateos, Jesús; Fafián Labora, Juan Antonio; Morente-López, Miriam; Lesende-Rodríguez, Iván; Monserrat, Lorenzo; Ódena, María A.; Oliveira, Eliandre de; De-Toro, Javier; Arufe, M.C. (PLOS, 2018-10-31)[Abstract] Hutchinson-Gilford progeria syndrome (HGPS) is a very rare fatal disease characterized for accelerated aging. Although the causal agent, a point mutation in LMNA gene, was identified more than a decade ago, the ... -
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
Mato-Basalo, Rocío; Morente-López, Miriam; Arntz, O.J.; Van de Loo, F.J.; Fafián Labora, Juan Antonio; Arufe, M.C. (MDPI, 2021-03-25)[Abstract] Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free ... -
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Silva-Fernández, Lucía; González-Rodríguez, Alba; De-Toro, Javier; Fafián Labora, Juan Antonio; Arufe, M.C. (Springer, 2022-10-20)[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...