Listar por autor "Meng, Weikun"
Mostrando ítems 1-4 de 4
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Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Cai, Xiaoyu; Pons, Françoise; Lebeau, Luc; Migonney, Véronique; Madry, Henning; Cucchiarini, Magali (Elsevier, 2020-12-28)[Abstract] Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ... -
Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Schmitt, Gertrud; Speicher-Mentges, Susanne; Falentin-Daudré, Céline; Leroux, Amélie; Madry, Henning; Migonney, Véronique; Cucchiarini, Magali (MDPI, 2020)[Abstract] Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
Rey-Rico, Ana; Madry, Henning; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cai, Xiaoyu; Meng, Weikun; Cucchiarini, Magali; Maihöfer, Johanna; Goebel, Lars; Zurakowski, David; Menger, Michael D.; Laschke, Matthias W. (Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
Meng, Weikun; Rey-Rico, Ana; Claudel, Mickaël; Schmitt, Gertrud; Speicher-Mentges, Susanne; Pons, Françoise; Lebeau, Luc; Venkatesan, Jagadeesh K.; Cucchiarini, Magali (MDPI, 2020-04-28)[Abstract] Scaffold-assisted gene therapy is a highly promising tool to treat articular cartilage lesions upon direct delivery of chondrogenic candidate sequences. The goal of this study was to examine the feasibility ...