Listar por autor "Manfredi-Lozano, María"
Mostrando ítems 1-6 de 6
-
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013)[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ... -
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
Gaytán, Francisco; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; García-Galiano, David; Ruiz-Pino, Francisco; Romero-Ruiz, Antonio; León, Silvia; Morales, Concepción; Cordido, Fernando; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013-01-21)[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ... -
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3
Heras, Violeta; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Sánchez-Tapia, María J.; Ruiz-Pino, Francisco; Roa, Juan; Lara-Chica, Maribel; Morrugares-Carmona, Rosario; Jouy, Nathalie; Abreu, Ana P.; Prevot, Vincent; Belsham, Denise; Vázquez, María J.; Calzado, Marco A.; Pinilla, Leonor; Gaytán, Francisco; Latronico, Ana C.; Kaiser, Ursula B.; Castellano, Juan M.; Tena-Sempere, Manuel (Public Library of Science (PLoS), 2019-11-07)[Abstract] Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; ... -
Perturbation of hypothalamic MicroRNA expression patterns in male rats after metabolic distress: impact of obesity and conditions of negative energy balance
Sangiao-Alvarellos, Susana; Pena-Bello, Lara; Manfredi-Lozano, María; Tena-Sempere, Manuel; Cordido, Fernando (Endocrine Society, 2014-02-11)[Abstract] The hypothalamus plays a crucial role in body weight homeostasis through an intricate network of neuronal circuits that are under the precise regulation of peripheral hormones and central transmitters. Although ... -
Role of neurokinin B in the control of female puberty and Its modulation by metabolic status
Navarro, Víctor M.; Ruiz-Pino, Francisco; Sánchez-Garrido, Miguel A.; García-Galiano, David; Hobbs, Samuel J.; Manfredi-Lozano, María; León, Silvia; Sangiao-Alvarellos, Susana; Castellano, Juan M.; Clifton, Donald K.; Pinilla, Leonor; Steiner, Robert A.; Tena-Sempere, Manuel (Society of Neuroscience, 2012-02-15)[Abstract] Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB–NK3R signaling in the ... -
Testicular expression of the Lin28/let-7 system: hormonal regulation and changes during postnatal maturation and after manipulations of puberty
Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; León, Silvia; Morales, Concepción; Cordido, Fernando; Gaytán, Francisco; Pinilla, Leonor; Tena-Sempere, Manuel (Nature, 2015-10-23)[Abstract] The Lin28/let-7 system, which includes the RNA-binding proteins, Lin28a/Lin28b, and let-7 miRNAs, has emerged as putative regulator of puberty and male gametogenesis; yet, its expression pattern and regulation ...