Listar por autor "Magalhaes, Joana"
Mostrando ítems 1-4 de 4
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Amentadione from the alga cystoseira usneoides as a novel osteoarthritis protective agent in an ex vivo co-culture OA model
Araújo, Nuna; Viegas, Carla S.B.; Zubía, Eva; Magalhaes, Joana; Ramos, Acácio; Carvalho, Maria M.; Cruz, Henrique; Sousa, Joao Paulo; Blanco García, Francisco J; Vermeer, Cees; Simes, Dina C. (MDPI, 2020-12-07)[Abstract] Osteoarthritis (OA) remains a prevalent chronic disease without effective prevention and treatment. Amentadione (YP), a meroditerpenoid purified from the alga Cystoseira usneoides, has demonstrated anti-inflammatory ... -
Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study
Widera, Pawel; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco García, Francico J; Magalhaes, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnes; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)[Abstract] Objectives. To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine ... -
Optical biomarkers for the diagnosis of osteoarthritis through Raman spectroscopy: radiological and biochemical validation using ex vivo human cartilage samples
Casal-Beiroa, Paula; Balboa-Barreiro, Vanesa; Oreiro, Natividad; Pértega-Díaz, Sonia; Blanco García, Francisco J; Magalhaes, Joana (MDPI, 2021-03-18)[Abstract] Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. Raman spectroscopy (RS) has been recently proposed as a label-free tool to detect molecular ... -
RGD-dendrimer-poly(L-lactic) acid nanopatterned substrates for the early chondrogenesis of human mesenchymal stromal cells derived from osteoarthritic and healthy donors
Rodríguez-Pereira, Cristina; Lagunas, Anna; Casanellas, Ignasi; Vida, Yolanda; Pérez-Inestrosa, Ezequiel; Andrades, José A.; Becerra, José; Samitier, Josep; Blanco García, Francisco J; Magalhaes, Joana (MDPI, 2020-05-13)[Abstract] Aiming to address a stable chondrogenesis derived from mesenchymal stromal cells (MSCs) to be applied in cartilage repair strategies at the onset of osteoarthritis (OA), we analyzed the effect of arginine–glyc ...