Now showing items 1-3 of 3

    • An integrated molecular diagnostic report for heart transplant biopsies using an ensemble of diagnostic algorithms 

      Parkes, Michael D.; Aliabadi, Arezu Z.; Cadeiras, Martin; Crespo-Leiro, María Generosa; Deng, Mario; Depasquale, Eugene C.; Goekler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; Loupy, Alexandre; Macdonald, Peter; Potena, Luciano; Zuckermann, Andreas; Halloran, Philip F. (Elsevier, 2019-02-06)
      [Abstract] BACKGROUND. We previously reported a microarray-based diagnostic system for heart transplant endomyocardial biopsies (EMBs), using either 3-archetype (3AA) or 4-archetype (4AA) unsupervised algorithms to estimate ...
    • Assessing the relationship between molecular rejection and parenchymal injury in heart transplant biopsies 

      Madill-Thomsen, Katelynn S.; Reeve, Jeff; Aliabadi-Zuckermann, Arezu; Cadeiras, Martin; Crespo-Leiro, María Generosa; Depasquale, Eugene D.; Deng, Mario; Goeckler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; MacDonald, Peter; Potena, Luciano; Shah, Keyur; Stehlik, Josef; Zuckermann, Andreas; Halloran, Philip F. (Wolters Kluwer, 2022-11)
      [Abstract] Background: The INTERHEART study (ClinicalTrials.gov #NCT02670408) used genome-wide microarrays to detect rejection in endomyocardial biopsies; however, many heart transplants with no rejection have late dysfunction ...
    • Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes 

      Halloran, Philip F.; Madill-Thomsen, Katelynn; Aliabadi-Zuckermann, Arezu Z.; Cadeiras, Martín; Crespo-Leiro, María Generosa; Depasquale, Eugene C.; Deng, Mario; Gökler, Johannes; Kim, Daniel H.; Kobashigawa, Jon; Macdonald, Peter; Potena, Luciano; Shah, Keyur; Stehlik, Josef; Zuckermann, Andreas (Elsevier, 2021-08-04)
      [Abstract] Background: The Molecular Microscope (MMDx) system classifies heart transplant endomyocardial biopsies as No-rejection (NR), Early-injury, T cell-mediated (TCMR), antibody-mediated (ABMR), mixed, and possible ...