Listar por autor "Jones, Elena"
Mostrando ítems 1-6 de 6
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Characterization and miRNA profiling of extracellular vesicles from human osteoarthritic subchondral bone multipotential stromal cells (MSCs)
Sanjurjo-Rodríguez, Clara; Crossland, Rachel E.; Reis, Monica; Pandit, Hemant; Wang, Xiao-nong; Jones, Elena (Hindawi, 2021-10-09)[Abstract] Osteoarthritis (OA) is a heterogeneous disease in which the cross-talk between the cells from different tissues within the joint is affected as the disease progresses. Extracellular vesicles (EVs) are known to ... -
Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients
Sanjurjo-Rodríguez, Clara; Baboolal, Thomas G.; Burska, Agata N.; Ponchel, Frederique; El-Jawhari, Jehan J.; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Nature Publishing Group, 2019-06-29)[Abstract] Osteoarthritis (OA) is the most common degenerative joint disorder. Multipotential stromal cells (MSCs) have a crucial role in joint repair, but how OA severity affects their characteristics remains unknown. ... -
Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction
Sanjurjo-Rodríguez, Clara; Altaie, Ala; Mastbergen, Simon; Baboolal, Thomas G.; Welting, Tim; Lafeber, Floris; Pandit, Hemant; McGonagle, Dennis; Jones, Elena (Frontiers Media S.A., 2020-10-14)[Abstract] Osteoarthritis (OA) is the most common musculoskeletal disorder. Although joint replacement remains the standard of care for knee OA patients, knee joint distraction (KJD), which works by temporarily off-loading ... -
Longitudinal evaluation of synovial fluid and synovial fluid MSC transcript changes in subjects undergoing joint distraction.
Baboolal, Thomas G.; Jansen, Mylène; Jones, Elena; Sanjurjo-Rodríguez, Clara; Welting, Tim; Emans, Pieter; Lafeber, Floris; McGonagle, Dennis; Mastbergen, Simon (BMJ Journals, 2019-05-27) -
Mesenchymal stem cell functionalization for enhanced therapeutic applications
Kouroupis, Dimitrios; Sanjurjo-Rodríguez, Clara; Jones, Elena; Correa, Diego (Mary Ann Liebert, 2019-02-14)[Abstract] Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact ... -
Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
Cuthbert, R.J.; Jones, Elena; Sanjurjo-Rodríguez, Clara; Lotfy, A.; Ganguly, P.; Churchman, S.M.; Kastana, P.; Tan, H.B.; McGonagle, Dennis; Papadimitriou, E.; Giannoudis, P.V. (MDPI, 2020-05-28)[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone formation and are ...