Listar por autor "Jansen, Mylène"
Mostrando ítems 1-13 de 13
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Aortic, musculoskeletal and organ characteristics on computed tomography in knee osteoarthritis – an explorative study in the IMI-APPROACH cohort
Harlianto, Netanja I.; de Jong, Pim A.; Foppen, Wouter; Bennink, Edwin; Bunk, Stijn; Mastbergen, Simon C.; Vorselaars, Adriane D.M.; Voortman, Mareye; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Popuri, Karteek; Beg, Mirza Faisal; Jansen, Mylène (Springer Nature, 2025-02-24)[Abstract] The systemic associations with knee osteoarthritis (KOA) are incompletely understood. This study explores aortic disease, musculoskeletal and organ findings in patients with KOA in relation to their symptoms or ... -
Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort
Jansen, Mylène; Hodgins, Diana; Mastbergen, Simon C.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Eckstein, Felix; Roemer, Frank W.; Wirth, Wolfgang (Springer Nature, 2024-03-27)[Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected ... -
Cohort profile: the Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers
van Helvoort, Eefje M.; van Spil, Willem E.; Jansen, Mylène; Welsing, Paco M.J.; Kloppenburg, Margreet; Loef, Marieke; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Bacardit, Jaume; Ladel, Christoph; Loughlin, John; Bay-Jensen, Anne C; Mobasheri, Ali; Larkin, Jonathan; Boere, Janneke; Weinans, Harrie; Lalande, Agnes; Marijnissen, Anne C.A.; Lafeber, Floris (BMJ, 2020-07-28)[Abstract] Purpose The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (APPROACH) consortium intends to prospectively describe in detail, preselected patients with knee osteoarthritis (OA), using ... -
Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort
Jansen, Mylène; Roemer, Frank W.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Lafeber, Floris; Welsing, Paco M.J.; Mastbergen, Simon C.; Wirth, Wolfgang (Springer, 2023-01-06)[Abstract] Objective: Longitudinal weight-bearing radiographic joint space width (JSW) and non-weight-bearing MRI-based cartilage thickness changes often show weak correlations. The current objective was to investigate ... -
Fluctuation of bone marrow lesions and inflammatory MRI markers over 2 years and concurrent associations with quantitative cartilage loss
Roemer, Frank W.; Jansen, Mylène; Maschek, Susanne; Mastbergen, Simon C.; Marijnissen, Anne C.A.; Wisser, Anna; Heiss, Rafael; Weinans, Harrie; Blanco García, Francisco J; Berenbaum, Francis; Kloppenburg, Margreet; Haugen, Ida Kristin; Eckstein, Felix; Hunter, David J.; Guermazi, Ali; Wirth, Wolfgang (Sage, 2024-10-26)[Abstract] Objective: To assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory markers is associated with change in quantitatively-assessed cartilage ... -
Longitudinal evaluation of synovial fluid and synovial fluid MSC transcript changes in subjects undergoing joint distraction.
Baboolal, Thomas G.; Jansen, Mylène; Jones, Elena; Sanjurjo-Rodríguez, Clara; Welting, Tim; Emans, Pieter; Lafeber, Floris; McGonagle, Dennis; Mastbergen, Simon C. (BMJ Journals, 2019-05-27) -
Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort
Jansen, Mylène; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Ladel, Christoph; Loef, Marieke; Lafeber, Floris; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)[Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ... -
Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping
van Helvoort, Eefje M.; Welsing, Paco M.J.; Jansen, Mylène; Gielis, Willem Paul; Loef, Marieke; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Bay-Jensen, Anne C; Ladel, Christoph; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Lafeber, Floris; Eijkelkamp, Niels; Mastbergen, Simon C. (BMJ, 2021-12-15)[Abstract] Objectives: Osteoarthritis (OA) patients with a neuropathic pain (NP) component may represent a specific phenotype. This study compares joint damage, pain and functional disability between knee OA patients with ... -
Predicted and actual 2-year structural and pain progression in the IMI-APPROACH knee osteoarthritis cohort
van Helvoort, Eefje M.; Jansen, Mylène; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francisco J; Haugen, Ida Kristin; Berenbaum, Francis; Bay-Jensen, Anne C; Ladel, Christoph; Lalande, Agnes; Larkin, Jonathan; Loughlin, John; Mobasheri, Ali; Weinans, Harrie; Widera, Pawel; Bacardit, Jaume; Welsing, Paco M.J.; Lafeber, Floris (Oxford Academic, 2023-01)[Abstract] Objectives: The IMI-APPROACH knee osteoarthritis study used machine learning (ML) to predict structural and/or pain progression, expressed by a structural (S) and pain (P) predicted-progression score, to select ... -
Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion
Heiss, Rafael; Laredo, Jean-Denis; Wirth, Wolfgang; Jansen, Mylène; Marijnissen, Anne C.A.; Lafeber, Floris; Lalande, Agnes; Weinans, Harrie; Blanco García, Francisco J; Berenbaum, Francis; Kloppenburg, Margreet; Haugen, Ida Kristin; Engelke, Klaus; Roemer, Frank W. (Elsevier, 2023-03)[Abstract] Objective: Osteoarthritis (OA) is a highly prevalent chronic condition. The subchondral bone plays an important role in onset and progression of OA making it a potential treatment target for disease-modifying ... -
Severity and progression of structural hand OA is not associated with progression of structural knee OA: the IMI-APPROACH cohort
Terpstra, Sietse E.S.; van de Stadt, Lotte A.; Berenbaum, Francis; Blanco García, Francisco J; Haugen, Ida Kristin; Mastbergen, Simon C.; Weinans, Harrie; Jansen, Mylène; Rosendaal, Frits R.; Kloppenburg, Margreet (Elsevier, 2024-05)[Abstract]. Objective. To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA. Methods. We used baseline and ... -
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort
Roemer, Frank W.; Jansen, Mylène; Marijnissen, Anne C.A.; Guermazi, Ali; Heiss, Rafael; Maschek, Susanne; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida Kristin; Ladel, Christoph; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Lafeber, Floris; Weinans, Harrie; Wirth, Wolfgang (BioMed Central, 2022-11-17)[Abstract] Background. The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index ... -
Test–retest precision and longitudinal cartilage thickness loss in the IMI-APPROACH cohort
Wirth, Wolfgang; Maschek, Susanne; Marijnissen, Anne C.A.; Lalande, Agnes; Blanco García, Francisco J; Berenbaum, Francis; van de Stadt, Lotte A.; Kloppenburg, Margreet; Haugen, Ida Kristin; Ladel, Christoph; Bacardit, Jaume; Wisser, Anna; Eckstein, Felix; Roemer, Frank W.; Lafeber, Floris; Weinans, Harrie; Jansen, Mylène (Elsevier, 2022-11-03)[Abstract] Objective. To investigate the test–retest precision and to report the longitudinal change in cartilage thickness, the percentage of knees with progression and the predictive value of the machine-learning-estimated ...
