Listar por autor "Iglesias Reinoso, Raquel"
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Detection of protein interactions based on GFP fragment complementation by fluorescence microscopy and spectrofluorometry
Torrado, Mario; Iglesias Reinoso, Raquel; Mikhailov, Alexander T. (Future Science, 2008)[Abstract] We have developed a set of simple modifications of the green fluorescent protein (GFP)fragment reassembly assay in bacteria that permits: (i)fluorescent microscopy visualization of GFP reassembly only 1-2 h after ... -
Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro
Torrado, Mario; Iglesias Reinoso, Raquel; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (SAPE / Society for Experimental Biology and Medicine, 2010)[Abstract] Brain natriuretic peptide/natriuretic peptide precursor B (NPPB) is one of the most studied genes in relation to heart failure (HF) conditions. However, it is still unclear as to whether alternative splicing ... -
Identificación y caracterización de genes con expresión diferencial izquierda-derecha en el miocardio ventricular neonatal : implicaciones fisiopatológicas
Iglesias Reinoso, Raquel (2010)[Resumen] El marco teórico conceptual consiste en la proposición de que la respuesta transcripcional del miocardio ventricular al estrés biomecánico se determina no solo por el tipo de sobrecarga hemodinámica (de ... -
Identification of candidate genes potentially relevant to chamber-specific remodeling in postnatal ventricular myocardium
Torrado, Mario; Iglesias Reinoso, Raquel; Nespereira, Beatriz; Mikhailov, Alexander T. (Hindawi, 2010)[Abstract] Molecular predisposition of postnatal ventricular myocardium to chamber-dependent (concentric or eccentric) remodeling remains largely elusive. To this end, we compared gene expression in the left (LV) versus ... -
Survival impact of previous statin therapy in patients hospitalized with COVID-19
Barge-Caballero, Eduardo; Marcos-Rodríguez, Pedro J.; Doménech, Nieves; Bou, Germán; Cid-Fernández, Javier; Iglesias Reinoso, Raquel; López Vázquez, Paula; Muñiz, Javier; Vázquez-Rodríguez, José M.; Crespo-Leiro, María Generosa (Elsevier, 2022-12-07)[Abstract] tIntroduction: Statin therapy might have a beneficial prognostic effect in patients with COVID-19, givenits immunomodulative, anti-inflammatory and anti-atherosclerotic properties. Our purpose was to testthis ... -
Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
Torrado, Mario; Iglesias Reinoso, Raquel; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (PLoS, 2011)[Abstract] Background. Myocardin (MYOCD), a potent transcriptional coactivator of smooth muscle (SM) and cardiac genes, is upregulated in failing myocardium in animal models and human end-stage heart failure (HF). However, ...