• Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress 

      Medina-Luna, Daniel; Santamaría-Olmedo, Mónica Guadalupe; Zamudio-Cuevas, Yessica; Martínez-Flores, Karina; Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Clavijo-Cornejo, Denise; Hernández-Díaz, Cristina; Olivos-Meza, Anell; Gómez-Quiroz, Luis Enrique; Gutiérrez-Ruiz, María Concepción; Pineda, Carlos; Blanco García, Francisco J; Reginato, Anthony M.; López-Reyes, Alberto (BMC, 2017-06-12)
      [Abstract] Background, Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this ...
    • Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes 

      López-Reyes, Alberto; Medina-Luna, Daniel; Santamaría-Olmedo, Mónica; Martínez-Flores, Karina; Zamudio-Cuevas, Yessica; Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Olivos-Meza, Anell; Camacho-Rea, Carmen; Fernández-Moreno, Mercedes; Blanco García, Francisco J; Pineda, Carlos (Springer, 2021-03-16)
      [Abstract] We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms ...