Listar por autor "Eirín-López, J.M."
Mostrando ítems 1-8 de 8
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Birth-and-death evolution with strong purifying selection in the histone H1 multigene family and the origin of "orphon" H1 genes
Eirín-López, J.M.; González-Tizón, Ana M.; Martínez-Lage, Andrés; Méndez, Josefina (Oxford University Press, 2004-10)[Abstract:] Histones are small basic nuclear proteins with critical structural and functional roles in eukaryotic genomes. The H1 multigene family constitutes a very interesting histone class gathering the greatest number ... -
Caracterización de los genes de histonas en el género Mytilus y evolución molecular de la familia multigénica H1
Eirín-López, J.M. (2004)[Resumen] INTRODUCCIÓN Las histonas son un grupo de proteínas básicas de pequeño tamaño presentes en las células eucariotas, involucradas en el empaquetamiento del ADN formando la fibra de cromatina. Existen cinco ... -
Common evolutionary origin and birth-and-death process in the replication-independent histone H1 isoforms from vertebrate and invertebrate genomes
Eirín-López, J.M.; Ruiz Lorenzo, María Fernanda; González-Tizón, Ana M.; Martínez-Lage, Andrés; Ausió, Juan; Sánchez Rodríguez, Lucas; Méndez, Josefina (Springer Nature, 2005-09)[Abstract]The H1 histone multigene family shows the greatest diversity of isoforms among the five histone gene families, including replication-dependent (RD) and replication-independent (RI) genes, according to their ... -
Early Genotoxic and Cytotoxic Effects of the Toxic Dinoflagellate Prorocentrum lima in the Mussel Mytilus galloprovincialis
Prego-Faraldo, María Verónica; Valdiglesias, Vanessa; Laffon, Blanca; Méndez, Josefina; Eirín-López, J.M. (Multidisciplinary Digital Publishing Institute, 2016)Okadaic acid (OA) and dinophysistoxins (DTXs) are the main toxins responsible for diarrhetic shellfish poisoning (DSP) intoxications during harmful algal blooms (HABs). Although the genotoxic and cytotoxic responses to OA ... -
Molecular and evolutionary analysis of mussel histone genes ("Mytilus" spp.): possible evidence of an "orphon origin" for H1 histone genes
Eirín-López, J.M.; González-Tizón, Ana M.; Martínez-Lage, Andrés; Méndez, Josefina (Springer Nature, 2002-09)[Abstract:] Linker histones are a divergent group of histone proteins with an independent evolutionary history in which, besides somatic subtypes, tissue- and differentiation-specific subtypes are included. In the present ... -
Molecular evolutionary characterization of the mussel "Mytilus" histone multigene family: first record of a tandemly repeated unit of five histone genes containing an H1 subtype with orphon features
Eirín-López, J.M.; Ruiz Lorenzo, María Fernanda; González-Tizón, Ana M.; Martínez-Lage, Andrés; Sánchez Rodríguez, Lucas; Méndez, Josefina (Springer Nature, 2004-02)[Abstract] The present work represents the first characterization of a clustered histone repetitive unit containing an H1 gene in a bivalve mollusk. To complete the knowledge on the evolutionary history of the histone ... -
Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates
Prego-Faraldo, María Verónica; Valdiglesias, Vanessa; Méndez, Josefina; Eirín-López, J.M. (Multidisciplinary Digital Publishing Institute, 2013)Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination in the oceans, producing high concentrations of potentially harmful biotoxins that are accumulated across the food chains. One such ... -
The CHROMEVALOA Database: A Resource for the Evaluation of Okadaic Acid Contamination in the Marine Environment Based on the Chromatin-Associated Transcriptome of the Mussel Mytilus galloprovincialis
Suárez-Ulloa, Victoria; Fernández-Tajes, Juan; Aguiar-Pulido, Vanessa; Rivera-Casas, Ciro; González-Romero, Rodrigo; Ausio, Juan; Méndez, Josefina; Dorado, Julián; Eirín-López, J.M.Okadaic Acid (OA) constitutes the main active principle in Diarrhetic Shellfish Poisoning (DSP) toxins produced during Harmful Algal Blooms (HABs), representing a serious threat for human consumers of edible shellfish. ...