Listar por autor "Carpintero-Fernández, Paula"

Mostrando ítems 1-5 de 5

    • Extracellular Vesicles Enriched in Connexin 43 Promote a Senescent Phenotype in Bone and Synovial Cells Contributing to Osteoarthritis Progression 

      Varela-Eirín, Marta; Carpintero-Fernández, Paula; Guitián-Caamaño, Amanda; Varela Vázquez, Adrián; García-Yuste, Alejandro; Sánchez Temprano, Agustín; Bravo López, Susana Belén; Yáñez-Cabanas, José; Fonseca, Eduardo; Largo, R.; Mobasheri, Ali; Caeiro, José Ramón; Mayán, María D. (Springer Nature, 2022)
      [Abstract] The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that high ...

    • FASN activity is important for the initial stages of the induction of senescence 

      Fafián Labora, Juan Antonio; Carpintero-Fernández, Paula; Jordan, Samuel James Davison; Shikh-Bahaei, Tamanna; Abdullah, Sana Mohammad; Mahenthiran, Midusa; Rodríguez-Navarro, José Antonio; Niklison-Chirou, María Victoria; O’Loghlen, Ana (Springer Nature, 2019-04-08)
      [Abstract] Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is ...

    • Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence 

      Carpintero-Fernández, Paula; Borghesan, Michela; Eleftheriadou, Olga; Pan-Castillo, Belén; Fafián Labora, Juan Antonio; Mitchell, Tom P.; Yuste, Alejandro; Ogrunc, Muge; Nightingale, Thomas D.; Mayán, María; O'Loghlen, Ana (Nature, 2022-02-19)
      [Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...

    • Senolytic Activity of Small Molecular Polyphenols from Olive Restores Chondrocyte Redifferentiation and Promotes a Pro-Regenerative Environment in Osteoarthritis 

      Varela-Eirín, Marta; Carpintero-Fernández, Paula; Sánchez Temprano, Agustín; Varela Vázquez, Adrián; Luis Paíno, Carlos; Casado-Díaz, Antonio; Calañas Continente, Alfonso; Mato-Abad, Virginia; Fonseca, Eduardo; Kandouz, Mustapha; Blanco, Alfonso; Caeiro, José Ramón; Mayan, Maria D. (Impact Journals LLC, 2020-08-03)
      [Abstract] Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and ...

    • Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3 

      Borghesan, Michela; Fafián Labora, Juan Antonio; Eleftheriadou, Olga; Carpintero-Fernández, Paula; Paez-Ribes, Marta; Vizcay-Barrena, Gema; Swisa, Avital; Kolodkin-Gal, Dror; Ximénez-Embún, Pilar; Lowe, Robert; Martín-Martín, Belén; Peinado, Héctor; Muñoz, Javier; Fleck, Roland A.; Dor, Yuval; Ben-Porath, Ittai; Vossenkamper, Anna; Muñoz-Espin, Daniel; O’Loghlen, Ana (Cell Press, 2019-06-25)
      [Abstract] Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is ...