Listar por autor "Blanco García, Francico J"
Mostrando ítems 1-12 de 12
-
An atlas of the knee joint proteins and their role in osteoarthritis defined by literature mining
Paz-González, Rocío; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Quaranta, Patricia; Picchi, Florencia; Blanco García, Francico J; Ruiz-Romero, Cristina (Elsevier, 2023-08)[Abstract] Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common ... -
Anti-inflammatory activity of APPA (Apocynin and Paeonol) in human articular chondrocytes
Fernández-Moreno, Mercedes; Hermida-Gómez, Tamara; Larkins, Nicholas; Reynolds, Alan; Blanco García, Francico J (MDPI, 2024-01-16)[Abstract] Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the joint space which results in pain. The current pharmacological treatment of OA is inadequate and pharmacological ... -
Anti-inflammatory potential of ulvan
Flórez-Fernández, Noelia; Rodríguez-Coello, Arianna; Latire, Thomas; Bourgougnon, Natalie; Torres, María Dolores; Buján, Manuela; Muíños, Alexandra; Muíños, Antonio; Meijide-Faílde, Rosa; Blanco García, Francico J; Vaamonde-García, Carlos; Domínguez, Herminia (Elsevier, 2023-12-31)[Abstract] Green seaweeds are a widespread group of marine macroalgae that could be regarded as biorenewable source of valuable compounds, in particular sulfated polysaccharides like ulvans with interesting biological ... -
Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials: the IMI-APPROACH study
Widera, Pawel; Welsing, Paco M.J.; Danso, Samuel O.; Peelen, Sjaak; Kloppenburg, Margreet; Loef, Marieke; Marijnissen, Anne C.; van Helvoort, Eefje M.; Blanco García, Francico J; Magalhaes, Joana; Berenbaum, Francis; Haugen, Ida K.; Bay-Jensen, Anne-C.; Mobasheri, Ali; Ladel, Christoph; Loughlin, John; Lafeber, Floris P.J.G.; Lalande, Agnes; Larkin, Jonathan; Weinans, Harrie; Bacardit, Jaume (Elsevier, 2023-12)[Abstract] Objectives. To efficiently assess the disease-modifying potential of new osteoarthritis treatments, clinical trials need progression-enriched patient populations. To assess whether the application of machine ... -
Expert recommendations on the interleukin 6 blockade in patients with rheumatoid arthritis
Tornero Molina, Jesús; Balsa Criado, Alejandro; Blanco García, Francico J; Blanco Alonso, Ricardo; Bustabad, Sagrario; Calvo Alen, Jaime; Corominas, Héctor; Fernández Nebro, Antonio; Román Ivorra, José Andrés; Sanmartí, Raimon (Elsevier, 2020-07)[Abstract] Objective: To draft recommendations on interleukin 6 (IL-6) blockade in rheumatoid arthritis (RA), based on best evidence and experience. Methods: A group of 10 experts on IL-6 blockade in RA was selected. ... -
Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort
Jansen, Mylène P.; Roemer, Frank W.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Wirth, Wolfgang (Springer, 2023-01-06)[Abstract] Objective: Longitudinal weight-bearing radiographic joint space width (JSW) and non-weight-bearing MRI-based cartilage thickness changes often show weak correlations. The current objective was to investigate ... -
Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis
Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Fernández-López, Carlos; Oreiro, Natividad; de-Toro, Javier; Blanco García, Francico J (BioMed Central, 2023-03-30)[Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ... -
Is osteoarthritis a mitochondrial disease?: what is the evidence
Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Blanco García, Francico J (Wolters Kluwer, 2022-01)[Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ... -
Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort
Jansen, Mylène P.; Wirth, Wolfgang; Bacardit, Jaume; van Helvoort, Eefje M.; Marijnissen, Anne C.A.; Kloppenburg, Margreet; Blanco García, Francico J; Haugen, Ida K.; Berenbaum, Francis; Ladel, Christoph H.; Loef, Marieke; Lafeber, Floris P.J.G.; Welsing, Paco M.J.; Mastbergen, Simon C.; Roemer, Frank W. (AME, 2023-05)[Abstract] In the Innovative Medicine’s Initiative Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) knee osteoarthritis (OA) study, machine learning models were trained to predict the ... -
Prognostic model to predict the incidence of radiographic knee osteoarthritis
Paz-González, Rocío; Balboa-Barreiro, Vanesa; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco García, Francico J (BMJ, 2024-01-05)[Abstract] Objective: Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful ... -
Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion
Heiss, Rafael; Laredo, Jean-Denis; Wirth, Wolfgang; Jansen, Mylène P.; Marijnissen, Anne C.A.; Lafeber, Floris P.J.G.; Lalande, Agnes; Weinans, Harrie H.; Blanco García, Francico J; Berenbaum, Francis; Kloppenburg, Margreet; Haugen, Ida K.; Engelke, Klaus; Roemer, Frank W. (Elsevier, 2023-03)[Abstract] Objective: Osteoarthritis (OA) is a highly prevalent chronic condition. The subchondral bone plays an important role in onset and progression of OA making it a potential treatment target for disease-modifying ... -
Seven-chain adaptive immune receptor repertoire analysis in rheumatoid arthritis reveals novel features associated with disease and clinically relevant phenotypes
Aterido, Adriá; López-Lasanta, María; Blanco García, Francico J; Juan-Mas, Antonio; García-Vivar, María Luz; Erra, Alba; Pérez-García, Carolina; Sánchez-Fernández, Simón Ángel; Sanmartí, Raimón; Fernández-Nebro, Antonio; Alperi-López, Mercedes; Tornero, Jesús; Ortiz, Ana María; Marras Fernández-Cid, Carlos; Palau, Núria; Pan, Wenjing; Byrne-Steele, Miranda; Starenki, Dmytro; Weber, Daniel; Rodríguez-Nunez, Iván; Han, Jian; Myers, Richard M.; Marsal, Sara; Juliá, Antonio (Springer Nature, 2024-03-11)