Listar por autor "Avecilla, Fernando"
Mostrando ítems 1-14 de 14
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A New Family of Iron(II)-Cyclopentadienyl Compounds Shows Strong Activity Against Colorectal and Triple Negative Breast Cancer Cells
Pilon, Adhan; Brás, Ana Rita; Côrte-Real, Leonor; Avecilla, Fernando; Costa, Paulo J.; Preto, Ana; García, M. Helena; Valente, Andreia (MDPI, 2020-03-30)[Abstract] A family of compounds with the general formula [Fe(η5-C5H5)(CO)(PPh3)(NCR)]+ has been synthesized (NCR = benzonitrile (1); 4-hydroxybenzonitrile (2); 4-hydroxymethylbenzonitrile (3); 4-aminobenzonitrile (4); ... -
Axentes químicos sensibilizantes
Avecilla, Fernando (Universidade da Coruña, 2014)[Resumo] Estudo e análise das enfermidades profesionais causadas por axentes químicos sensibilizantes. Clasificación dos axentes químicos sensibilizantes e dos seus análogos en función dos efectos que producen. -
Clasificación dos compostos de níquel en función das súas propiedades canceríxenas e mutáxenas de acordo coas directivas 2008/58/CE e 2009/2/CE da Comisión das Comunidades Europeas
Avecilla, Fernando (Universidade da Coruña, 2013)[Resumo] Análise das directivas 2008/58/CE e 2009/2/CE, nas cales se aborda a clasificación dos compostos de níquel –con numerosas aplicacións de uso cotián– en canceríxenos e mutáxenos, desde o punto de vista da base ... -
Complejos de itrio y lantánidos con macrobiciclos axiales base de Schiff
Avecilla, Fernando (1998)[Resumen] En la presente Tesis Doctoral se describe la síntesis y caracterización de complejos de itrio y lantánidos con receptores macrocíclicos del tipo criptando con espaciadores que contienen anillos aromáticos ... -
Design and Development of Small-Molecule Arylaldoxime/5-Nitroimidazole Hybrids as Potent Inhibitors of MARK4: a Promising Approach for Target-Based Cancer Therapy
Peerzada, Mudasir Nabi; Khan, Parvez; Khan, Nashrah Sharif; Avecilla, Fernando; Siddiqui, Shadab Miyan; Hassan, Imtaiyaz; Azam, Amir (American Chemical Society, 2020-09-01)[Abstract] Microtubule affinity-regulating kinase 4 (MARK4), a member of the serine/threonine kinase family, is an emerging therapeutic target in anticancer drug discovery paradigm due to its involvement in regulation of ... -
Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents
Avecilla, Fernando; Tariq, Saba; Mondal, Neelima; Azam, Amir; Sharma, Guru Prasad (Elsevier, 2018)[Abstract] In an effort to develop novel antiamoebic scaffolds having better efficacy than the standard drug metronidazole (IC50 = 1.80 μM) used against Entamoeba histolytica, quinazolin-4(3H)-one Schiff base conjugates ... -
Designing binuclear transition metal complexes: a new example of the versatility of N,N′-bis(2-aminobenzyl)-4,13-diaza-18-crown-6
Vaiana, Lea; Platas-Iglesias, Carlos; Esteban-Gómez, David; Avecilla, Fernando; Clemente-Juan, Juan Modesto; Real, José Antonio; Blas, Andrés de; Rodríguez-Blas, Teresa (Royal Society of Chemistry, 2005-04-27)[Abstract] N,N′-Bis(2-aminobenzyl)-4,13-diaza-18-crown-6 (L) is a versatile receptor able to adapt to the coordinative preferences of different metal cation guests. With first-row transition metal ions, L tends to form ... -
Enfermidades profesionais relacionadas coa exposición ao amianto
Avecilla, Fernando; López-Arranz, Asunción; Feal Fachal, María (Universidade da Coruña, Servizo de Publicacións, 2017)[Resumo] Neste traballo realizamos un estudo das doenzas causadas pola introdución do amianto no corpo humano, con dous obxectivos: por unha banda, aclarar cales son consideradas enfermidades profesionais en España, do ... -
First Iron(II) Organometallic Compound Acting as ABCB1 Inhibitor
Pilon, Adhan; Avecilla, Fernando; Mohai, Miklós; Enyedy, Éva Anna; Rácz, Bálint; Spengler, Gabriella; Garcia, Maria Helena; Valente, Andreia (Elsevier, 2023-05-13)[Abstract] Five new iron (II) complexes bearing imidazole-based (Imi-R) ligands with the general formula [Fe(η5-C5H5)(CO)(PPh3)(Imi-R)][CF3SO3] were synthesized and fully characterized by several spectroscopic and analytical ... -
Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane
Avecilla, Fernando; Pilon, Adhan; Rácz, Bálint; Gátszegi, Gerda T.; Spengler, Gabriella; Robalo, M. Paula; Enyedy, Éva Anna; Garcia, Maria Helena; Valente, Andreia (Elsevier, 2023)[Abstract] Structure-activity studies aiming to understand the role of each coligand in the formulation of new metallodrugs is an important subject. In that frame, six new compounds with general formula [Fe(η5-C5H5)(dppe ... -
Mononuclear/Binuclear [VIVO]/[VVO2] Complexes Derived from 1,3-Diaminoguanidine and Their Catalytic Application for the Oxidation of Benzoin via Oxygen Atom Transfer
Maurya, Mannar; Kumar, Naveen; Avecilla, Fernando (ACS, 2023-01-10)[Abstract] Ligands H4sal-dag (I) and H4Brsal-dag (II) derived from 1,3-diaminoguanidine and salicylaldehyde or 5-bromosalicylaldehyde react with one or 2 mol equivalent of vanadium precursor to give two different series ... -
Polymer-Supported Oxidovanadium(IV) Complexes and Their Catalytic Applications in One-Pot Multicomponent Reactions Producing Biologically Active 2,4,5-Trisubstituted-1H-imidazoles
Maurya, Mannar; Nandi, Monojit; Patter, Akhil; Avecilla, Fernando; Ghosh, Kaushik (MDPI, 2023-03-19)[Abstract] Two new monobasic tridentate O⁀N⁀N donor ligands, HL1 (I) and HL2 (II) have been obtained in two steps by reacting phenylhydrazine and salicylaldehyde or 3,5-di-tert-butylsalicylaldehyde and then reacting the ... -
Receptor versus counterion: capability of N,N′‐Bis(2‐aminobenzyl)‐diazacrowns for giving endo‐ and/or exocyclic coordination of ZnII
Vaiana, Lea; Platas-Iglesias, Carlos; Esteban-Gómez, David; Avecilla, Fernando; Blas, Andrés de; Rodríguez-Blas, Teresa (Wiley, 2007-03-20)[Abstract] The structure of ZnII complexes with receptors L1 and L2[L1 = N,N′‐bis(2‐aminobenzyl)‐1,10‐diaza‐15‐crown‐5 and L2 = N,N′‐bis(2‐aminobenzyl)‐4,13‐diaza‐18‐crown‐6] was studied both in the solid state and in ... -
Solution-State Cooperative Luminescence Upconversion in Molecular Ytterbium Dimers
Avecilla, Fernando; Soro, Lohona K.; Knighton, Richard C.; Thor, Waygen; Przybilla, Frédéric; Jeannin, Olivier; Esteban-Gómez, David; Platas-Iglesias, Carlos; Charbonnière, Loïc J. (Wiley, 2023)[Abstract] Two homometallic ytterbium dimers are prepared and their solution-state photoluminescence and upconversion properties are investigated. Both complexes exhibit two-photon cooperative luminescence upconversion in ...