Listar por autor "Álvarez-Fraga, Laura"
Mostrando ítems 1-14 de 14
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Analysis of the Role of the LH92_11085 Gene of a Biofilm Hyper-Producing Acinetobacter baumannii Strain on Biofilm Formation and Attachment to Eukaryotic Cells
Álvarez-Fraga, Laura; Pérez Gómez, Astrid; Rumbo-Feal, Soraya; Merino Carballeira, María; Vallejo, J. A.; Ohneck, Emily J.; Edelmann, Richard E.; Beceiro Casas, Alejandro; Vázquez-Ucha, Juan Carlos; Valle, Jaione; Actis, Luis; Bou, Germán; Poza, Margarita (Taylor & Francis, 2016-05-18)[Abstract] Acinetobacter baumannii is a nosocomial pathogen that has a considerable ability to survive in the hospital environment partly due to its capacity to form biofilms. The first step in the process of establishing ... -
Caracterización de nuevos factores de virulencia del patógeno nosocomial Acinetobacter baumannii
Álvarez-Fraga, Laura (2018)[Resumo] Acinetobacter baumannii é un patóxeno oportunista que xurdiu nos últimos anos como un dos microorganismos máis perigosos dentro do ambiente hospitalario. Na presente tese doutoral caracterizáronse dous novos ... -
Complete Genome Sequence of the Multiresistant Acinetobacter baumannii Strain AbH12O-A2, Isolated during a Large Outbreak in Spain
Merino Carballeira, María; Álvarez-Fraga, Laura; Gómez, Manuel J.; Aransay, Ana María; Lavín, José Luis; Chaves Sánchez, Fernando; Bou, Germán; Poza, Margarita (American Society for Microbiology (ASM), 2014-11-13)[Abstract] We report the complete genome sequence of Acinetobacter baumannii strain AbH12O-A2, isolated during a large outbreak in Spain. The genome has 3,875,775 bp and 3,526 coding sequences, with 39.4% G+C content. The ... -
Contribution of the A. baumannii A1S_0114 gene to the interaction with eukaryotic cells and virulence
Rumbo-Feal, Soraya; Pérez Gómez, Astrid; Ramelot, Theresa A.; Álvarez-Fraga, Laura; Vallejo, J. A.; Beceiro Casas, Alejandro; Ohneck, Emily J.; Arivett, Brock A.; Merino Carballeira, María; Fiester, Steven E.; Kennedy, Michael A.; Actis, Luis; Bou, Germán; Poza, Margarita (Frontiers Media, 2017-04-03)[Abstract] Genetic and functional studies showed that some components of the Acinetobacter baumannii ATCC 17978 A1S_0112-A1S_0119 gene cluster are critical for biofilm biogenesis and surface motility. Recently, our group ... -
Draft Genome Sequence of the Biofilm-Hyperproducing Acinetobacter baumannii Clinical Strain MAR002
Álvarez-Fraga, Laura; López Díaz, María; Merino Carballeira, María; Rumbo-Feal, Soraya; Tomás, María; Bou, Germán; Poza, Margarita (American Society for Microbiology (ASM), 2015-07-23)[Abstract] We report the draft genome sequence of Acinetobacter baumannii strain MAR002, a biofilm-hyperproducing clinical strain isolated during the study CP/09/0033 (GEIH/REIPI-Ab2010, Spain). The genome of A. baumannii ... -
Draft Genome Sequences of Two Epidemic OXA-48-Producing Klebsiella pneumoniae Clinical Strains Isolated during a Large Outbreak in Spain
Poza, Margarita; Gato, Eva; Álvarez-Fraga, Laura; Vallejo, J. A.; Rumbo-Feal, Soraya; Martínez Guitián, Marta; Beceiro Casas, Alejandro; Bou, Germán; Pérez Gómez, Astrid (American Society for Microbiology, 2018)[Abstract] We report here the draft genome sequences of Klebsiella pneumoniae strains Kp1803 and Kp3380 isolated during a large outbreak at A Coruña Hospital in Spain. The final genome assemblies for Kp1803 and Kp3380 ... -
Genome Sequence of a Clinical Strain of Acinetobacter baumannii Belonging to the ST79/PFGE-HUI-1 Clone Lacking the AdeABC (Resistance-Nodulation-Cell Division-Type) Efflux Pump
López Díaz, María; Álvarez-Fraga, Laura; Gato, Eva; Blasco, Lucía; Poza, Margarita; Fernández-García, L.; Bou, Germán; Tomás, María (American Society for Microbiology (ASM), 2016-09-08)[Abstract] Increased expression of chromosomal genes for resistance-nodulation-cell division-type efflux systems plays a major role in the multidrug resistance of Acinetobacter baumannii. Little is known about the genetic ... -
Global assessment of small RNAs reveals a non-coding transcript involved in biofilm formation and attachment in Acinetobacter baumannii ATCC 17978
Álvarez-Fraga, Laura; Rumbo-Feal, Soraya; Pérez Gómez, Astrid; Gómez, Manuel J.; Gayoso Babío, Carmen María; Vallejo, J. A.; Ohneck, Emily J.; Valle, Jaione; Actis, Luis; Beceiro Casas, Alejandro; Bou, Germán; Poza, Margarita (PLoS, 2017-08-01)[Abstract] Many strains of Acinetobacter baumannii have been described as being able to form biofilm. Small non-coding RNAs (sRNAs) control gene expression in many regulatory circuits in bacteria. The aim of the present ... -
In-Depth Analysis of the Role of the Acinetobactin Cluster in the Virulence of Acinetobacter baumannii
Conde-Pérez, Kelly; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Ageitos, Lucía; Rumbo-Feal, Soraya; Martínez Guitián, Marta; Trigo Tasende, Noelia; Rodríguez, Jaime; Bou, Germán; Jiménez, Carlos; Beceiro Casas, Alejandro; Poza, Margarita (Frontiers, 2021-10-05)[Abstract] Acinetobacter baumannii is a multidrug-resistant pathogen that represents a serious threat to global health. A. baumannii possesses a wide range of virulence factors that contribute to the bacterial pathogenicity. ... -
Involvement of HisF in the persistence of Acinetobacter baumannii during a pneumonia infection
Martínez Guitián, Marta; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Conde-Pérez, Kelly; Lasarte-Monterrubio, Cristina; Vallejo, J. A.; Bou, Germán; Poza, Margarita; Beceiro Casas, Alejandro (Frontiers, 2019)[Abstract] Acinetobacter baumannii is currently considered one of themost problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii ... -
Kpi, a Chaperone-Usher Pili System Associated with the Worldwide-Disseminated High-Risk Clone Klebsiella Pneumoniae ST-15
Gato, Eva; Vázquez-Ucha, Juan Carlos; Rumbo-Feal, Soraya; Álvarez-Fraga, Laura; Vallejo, J. A.; Martínez Guitián, Marta; Beceiro Casas, Alejandro; Ramos Vivas, Jose; Sola-Campoy, Pedro Juan; Pérez-Vázquez, María; Oteo, Jesús; Rodiño-Janeiro, Bruno Kotska; Romero, Antonio; Poza, Margarita; Bou, Germán; Pérez Gómez, Astrid (National Academy of Sciences, 2020-07-08)[Abstract] Control of infections caused by carbapenem-resistant Klebsiella pneumoniae continues to be challenging. The success of this pathogen is favored by its ability to acquire antimicrobial resistance and to spread ... -
Pneumonia infection in mice reveals the involvement of the feoA gene in the pathogenesis of Acinetobacter baumannii
Poza, Margarita; Álvarez-Fraga, Laura; Vázquez-Ucha, Juan Carlos; Martínez Guitián, Marta; Vallejo, J. A.; Bou, Germán; Beceiro Casas, Alejandro (Taylor and Francis, 2018)[Abstract] Acinetobacter baumannii has emerged in the last decade as an important nosocomial pathogen. To identify genes involved in the course of a pneumonia infection, gene expression profiles were obtained from A. ... -
Syzygium aromaticum (clove) and Thymus zygis (thyme) essential oils increase susceptibility to colistin in the nosocomial pathogens Acinetobacter baumannii and Klebsiella pneumoniae
Poza, Margarita; Vázquez-Ucha, Juan Carlos; Martínez Guitián, Marta; Lasarte-Monterrubio, Cristina; Conde-Pérez, Kelly; Arca-Suárez, Jorge; Álvarez-Fraga, Laura; Pérez Gómez, Astrid; Crecente-Campo, José; Alonso, María J.; Bou, Germán; Beceiro Casas, Alejandro (Elsevier, 2020)[Abstract] The discovery of new antibiotics that are effective against Acinetobacter baumannii and Enterobacteralesis a research priority. Several essential oils (EOs) have displayed some antimicrobial activity and could ... -
Whole Transcriptome Analysis of Acinetobacter baumannii Assessed by RNA-Sequencing Reveals Different mRNA Expression Profiles in Biofilm Compared to Planktonic Cells
Rumbo-Feal, Soraya; Gómez, Manuel J.; Gayoso Babío, Carmen María; Álvarez-Fraga, Laura; Cabral, M. P.; Aransay, Ana María; Rodríguez-Ezpeleta, Naiara; Fullaondo, Ane; Valle, Jaione; Tomás, María; Bou, Germán; Poza, Margarita (PLOS, 2013-08-30)[Abstract] Acinetobacter baumannii has emerged as a dangerous opportunistic pathogen, with many strains able to form biofilms and thus cause persistent infections. The aim of the present study was to use high-throughput ...
