Listar por autor "Sanjurjo-Rodríguez, Clara"
Mostrando ítems 21-33 de 33
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Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells
Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)[Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ... -
Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features
Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)[Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ... -
Induced pluripotent stem cells for cartilage repair: current status and future perspectives
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)[Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ... -
Ingeniería Tisular del hueso y el cartílago empleando células mesenquimales estromales y biomateriales
Sanjurjo-Rodríguez, Clara (2016)[Resumo]A artrose (OA) é a patoloxía reumática máis prevalente e, na actualidade, non existe un tratamento efectivo. Unha das causas deste trastorno é o desenvolvemento secundario tras unha lesión na cartilaxe hialina ... -
Longitudinal evaluation of synovial fluid and synovial fluid MSC transcript changes in subjects undergoing joint distraction.
Baboolal, Thomas G.; Jansen, Mylène; Jones, Elena; Sanjurjo-Rodríguez, Clara; Welting, Tim; Emans, Pieter; Lafeber, Floris; McGonagle, Dennis; Mastbergen, Simon (BMJ Journals, 2019-05-27) -
Mesenchymal stem cell functionalization for enhanced therapeutic applications
Kouroupis, Dimitrios; Sanjurjo-Rodríguez, Clara; Jones, Elena; Correa, Diego (Mary Ann Liebert, 2019-02-14)[Abstract] Culture expansion of MSCs has detrimental effects on various cell characteristics and attributes (e.g., phenotypic changes and senescence), which, in addition to inherent interdonor variability, negatively impact ... -
Mesenchymal stem cells from human amniotic membrane
Sanjurjo-Rodríguez, Clara; Díaz-Prado, Silvia; Hermida-Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J (Springer, 2014)[Abstract] The human amnion or amniotic membrane (HAM) has emerged as a novel and alternative source of stem cells. This tissue presents a reservoir of two types of stem cells from different embryological origins: human ... -
Ovine mesenchymal stromal cells for osteochondral tissue engineering
Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2017-04) -
Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering
Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fernández Vázquez, Tania; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (PLoS ONE, 2017-01-31)[Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ... -
Regulation of Angiogenesis Discriminates Tissue Resident MSCs from Effective and Defective Osteogenic Environments
Cuthbert, R.J.; Jones, Elena; Sanjurjo-Rodríguez, Clara; Lotfy, A.; Ganguly, P.; Churchman, S.M.; Kastana, P.; Tan, H.B.; McGonagle, Dennis; Papadimitriou, E.; Giannoudis, P.V. (MDPI, 2020-05-28)[Abstract] Background: The biological mechanisms that contribute to atrophic long bone non-union are poorly understood. Multipotential mesenchymal stromal cells (MSCs) are key contributors to bone formation and are ... -
Tips and Tricks for Successfully Culturing and Adapting Human Induced Pluripotent Stem Cells [Protocol]
Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; López-Baltar, Isidoro; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (Cell Press, 2021-12)[Abstract] Reprogramming somatic cells toward pluripotency became possible over a decade ago. Since then, induced pluripotent stem cells (iPSCs) have served as a versatile and powerful tool not only for basic research but ... -
Usefulness of mesenchymal cell lines for bone and cartilage regeneration research
Piñeiro-Ramil, María; Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (MDPI, 2019-12-13)[Abstract] The unavailability of sufficient numbers of human primary cells is a major roadblock for in vitro repair of bone and/or cartilage, and for performing disease modelling experiments. Immortalized mesenchymal ... -
Versatility of induced Pluripotent Stem Cells (iPSCs) for improving the knowledge on musculoskeletal diseases
Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Piñeiro-Ramil, María; Rodríguez-Fernández, Silvia; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J; Díaz-Prado, Silvia (MDPI, 2020-08-25)[Abstract] Induced pluripotent stem cells (iPSCs) represent an unlimited source of pluripotent cells capable of di erentiating into any cell type of the body. Several studies have demonstrated the valuable use of iPSCs ...