Browsing by Author "Laffon, Blanca"

Now showing items 21-40 of 53

    • Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways 

      Marcos Pérez, Diego; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Millán-Calenti, José Carlos; Strasser, Barbara; Gostner, Johanna; Fuchs, Dietmar; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (Elsevier para AMDA (The Society for Post-Acute and Long-Term Cara Medicine), 2017-08-08)

    • Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay as a diagnostic tool 

      Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (Oxford, 2018-01-13)
      [Abstract] Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of ...

    • Genetic Polymorphism in Cytochrome P450 1B1 in a Spanish Population [Short Communication] 

      Pérez-Cadahía, Beatriz; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Wiley, 2007-06-02)

    • Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HEPG2, A172 and SH-SY5Y) 

      Brandão, Fátima; Fernández‐Bertólez, Natalia; Rosário, Fernada; Bessa, Maria João; Fraga, Sónia; Pásaro, Eduardo; Teixeira, João; Laffon, Blanca; Valdiglesias, Vanessa; Costa, C. (2020)
      [Abstrac] Titanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern about the possible hazards that TiO2 NPs may pose to ...

    • Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)
      [Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ...

    • Immune activation in older-aged individuals is associated with genetic instability (or vice versa) 

      Gostner, Johanna; Sánchez-Flores, María; Marcos-Pérez, Diego; Lorenzo-López, Laura; Maseda, Ana; Millán-Calenti, José Carlos; Fuchs, Dietmar; Bonassi, Stefano; Pásaro, Eduardo; Laffon, Blanca; Valdiglesias, Vanessa (De Gruyter, 2019-06-15)

    • Immune biomarkers in older adults: role of physical activity 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Lorenzo-López, Laura; Marcos Pérez, Diego; López-Cortón-Facal, Ana; Strasser, Barbara; Fuchs, Dietmar; Laffon, Blanca; Millán-Calenti, José Carlos; Pásaro, Eduardo (Taylor & Francis, 2017-05-19)
      [Abstract] Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and ...

    • Immunometabolism as predictor of frailty 

      Gostner, Johanna; Laffon, Blanca; Felder, Thomas (Impact Journals, 2021-11-30)

    • Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Méndez, Josefina (Elsevier, 2011-03-01)
      [Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ...

    • Inter-Laboratory Variation in DNA Damage Using a Standard Comet Assay Protocol 

      Forchhammer, Lykke; Ersson, Clara; Loft, Steffen; Möller, Lennart; Godschalk, Roger W. L.; Schooten, Frederik J. van; Jones, George D. D.; Higgins, Jennifer A.; Cooke, Marcus; Mistry, Vilas; Karbaschi, Mahsa; Collins, Andrew R.; Azqueta, Amaya; Phillips, David H.; Sozeri, Osman; Routledge, Michael N.; Nelson-Smith, Kirsty; Riso, Patrizia; Porrini, Marisa; Matullo, Giuseppe; Allione, Alessandra; Stępnik, Maciej; Komorowska, Magdalena; Teixeira, João Paulo; Costa, Solange; Corcuera, Laura-Ana; López de Cerain, Adela; Laffon, Blanca; Valdiglesias, Vanessa; Møller, Peter (Oxford University Press, 2012-07-27)
      [Abstract] There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would ...

    • Is salivary chromogranin A a valid psychological stress biomarker during sensory stimulation in people with advanced dementia? 

      Valdiglesias, Vanessa; Maseda, Ana; Lorenzo-López, Laura; Pásaro, Eduardo; Millán-Calenti, José Carlos; Laffon, Blanca (IOS Press, 2016-12-20)
      [Abstract] Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation ...

    • Low Vitamin D Levels and Frailty Status in Older Adults: a Systematic Review and Meta-Analysis 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Bonassi, Stefano; Costa, Solange; Teixeira, João; Fernández-Tajes, Juan; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (2020)
      [Abstract] Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low ...

    • Lymphocyte subsets in a population of nonfrail elderly individuals 

      Valdiglesias, Vanessa; Sánchez-Flores, María; Maseda, Ana; Marcos Pérez, Diego; Millán-Calenti, José Carlos; Pásaro, Eduardo; Lorenzo-López, Laura; Laffon, Blanca (Taylor & Francis, 2015-07-13)
      [Abstract] Age-related frailty is characterized by increased vulnerability to stress due to decline in homeostatic reserve, which results in increased risk of adverse health outcomes including disability, hospitalization, ...

    • “Micronuclei and Disease” special issue: Aims, scope, and synthesis of outcomes 

      Fenech, Michael; Knasmueller, Siegfried; Knudsen, Lisbeth E.; Kirsch-Volders, Micheline; Deo, Permal; Franzke, Bernhard; Stopper, Helga; Andreassi, Maria-Grazia; Bolognesi, Claudia; Dhillon, Varinderpal S.; Laffon, Blanca; Wagner, Karl-Heinz; Bonassi, Stefano (2021)
      [Abastract] The purpose of the “Micronuclei and Disease” special issue (SI) is to: (i) Determine the level of evidence for association of micronuclei (MN), a biomarker of numerical and structural chromosomal aberrations, ...

    • Minimum Information for Reporting on the Comet Assay (MIRCA): Recommendations for Describing Comet Assay Procedures and Results 

      Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa; Koppen, Gudrun; Bonassi, Stefano; Milić, Mirta; Gajski, Goran; Costa, Solange; Teixeira, João; Pereira, Cristiana; Dusinska, Maria; Godschalk, Roger; Brunborg, Gunnar; Gützkow, Kristine Bjerve; Giovannelli, Lisa; Cooke, Marcus S.; Richling, Elke; Laffon, Blanca; Valdiglesias, Vanessa; Başaran, Nurşen; Del Bo’, Cristian; Zegura, Bojana; Novak, Matjaz; Stopper, Helga; Vodička, Pavel; Vodenkova, Sona; Andrade, Vanessa Moraes de; Sramkova, Monika; Gabelova, Alena; Collins, Andrew; Langie, Sabine (2020)
      [Abstract] The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental ...

    • Moving Towards Common Data Elements and Core Outcome Measures in Frailty Resea 

      Laffon, Blanca; Valdiglesias, Vanessa; Muscedere, John (Springer, 2020)
      [Abstract] With aging populations around the world, frailty is becoming more prevalent increasing the need for health systems and social systems to deliver optimal evidence based care. However, in spite of the growing ...

    • Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles 

      Valdiglesias, Vanessa; Costa, C.; Kiliç, Gözde; Costa, Solange; Pásaro, Eduardo; Laffon, Blanca; Teixeira, João Paulo (Elsevier, 2013-03-26)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have ...

    • Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Royal Society of Chemistry (Gran Bretaña), 2011-03-28)
      [Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ...

    • Okadaic Acid: More than a Diarrheic Toxin 

      Valdiglesias, Vanessa; Prego-Faraldo, María Verónica; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Multidisciplinary Digital Publishing Institute, 2013)
      Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary ...

    • Prescribed medication and malnourishment at risk of malnutrition 

      Maseda, Ana; Buján, Ana; Lorenzo-López, Laura; Valdiglesias, Vanessa; Laffon, Blanca; Millán-Calenti, José Carlos (Oxford, 2017-06-30)