Listar por autor "Antón-Aparicio, Luis M."

Mostrando ítems 41-49 de 49

    • Relevant networks involving the p53 signalling pathway in renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valbuena Ruvira, L.; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Master Publishing Group, 2011)
      [Abstract] Introduction: Renal cell carcinoma is the most common type of kidney cancer. A better understanding of the critical pathways and interactions associated with alterations in renal function and renal tumour ...

    • Role of taxanes in advanced prostate cancer 

      Cassinello Espinosa, J.; Carballido Rodríguez, J.; Antón-Aparicio, Luis M. (Springer, 2016-02-08)
      [Abstract] Advanced prostate cancer is an androgen-dependent disease for which the initial treatment is an androgen deprivation maneuver. However, some primary resistances to hormonal treatment occur with increasing incidence ...

    • Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells 

      Antón-Aparicio, Luis M.; Castosa, Raquel; Haz, Mar; Rodríguez, Marta; Blanco, Moisés; Valladares-Ayerbes, Manuel; Figueroa, Angélica (BioMed Central, 2014-07-10)
      [Abstract] Background. Vinflunine (VFL) is a microtubule-targeting drug that suppresses microtubule dynamics, showing anti-metastatic properties both in vitro and in living cancer cells. An increasing body of evidence ...

    • Searching for Hif1-α interacting proteins in renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2012-08-28)
      [Abstract] Introduction. Kidney tumours are frequently characterised by hypoxic conditions due to a local imbalance between oxygen (O2) supply and consumption. Hif1-α regulates angiogenesis, tumour growth, tumour progression, ...

    • State of the art in silico tools for the study of signaling pathways in cancer 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (MDPI, 2012-05-29)
      [Abstract] In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning ...

    • Sunitinib-induced asthenia: from molecular basis to clinical relief 

      Antón-Aparicio, Luis M.; Grande Pulido, Enrique; Aparicio Gallego, Guadalupe (Taylor & Francis, 2011-11-01)
      [Abstract] Asthenia-fatigue syndrome (AFS) is defined as a persistent, subjective sense of tiredness related to cancer or its treatment and greatly impacts quality of life among cancer patients. All tyrosine kinase inhibitors, ...

    • Tissue array analysis for the differentiation of gliosis from gliomas 

      Medina Villaamil, Vanessa; Álvarez García, A.; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Rivas López, A.; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Spandidos, 2011-03-22)
      [Abstract] The aim of this study was to provide a methodology to make a clear distinction between malignant tumors and morphologically similar benign processes, by examining the expression of EGFR, VEGF, HIF1-α, survivin, ...

    • Treatment of sunitinib-induced hypertension in solid tumor by nitric oxide donors 

      León-Mateos, L.; Mosquera, J.; Antón-Aparicio, Luis M. (Elsevier, 2015-09-10)
      [Abstract] Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) are overexpressed in the majority of renal cell carcinomas. This characteristic has supported the rationale of targeting VEGF-driven tumour ...

    • Tyrosine kinase inhibitors reprogramming immunity in renal cell carcinoma: rethinking cancer immunotherapy 

      Antón-Aparicio, Luis M.; Peláez Fernández, Ignacio; Cassinello Espinosa, J. (Springer, 2017-04-13)
      [Abstract] The immune system regulates angiogenesis in cancer by way of both pro- and antiangiogenic activities. A bidirectional link between angiogenesis and the immune system has been clearly demonstrated. Most antiangiogenic ...