Listar por autor "Fafián Labora, Juan Antonio"
Mostrando ítems 21-24 de 24
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Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage
Fafián Labora, Juan Antonio; Rodríguez-Navarro, José Antonio; O’Loghlen, Ana (Elsevier, 2020-07-07)[Abstract] Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ... -
Study of ferroptosis transmission by small extracellular vesicles in epithelial ovarian cancer cells
Alarcón-Veleiro, Carmen; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Vidal-Pampín, Andrea; Quindós-Varela, María; Al-Qatarneh, Thamer; Berrecoso, Germán; Vizoso-Vázquez, Ángel; Arufe, M.C.; Fafián Labora, Juan Antonio (MDPI, 2023-01-12)[Abstract] Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients ... -
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells
Mato-Basalo, Rocío; Morente-López, Miriam; Arntz, O.J.; Van de Loo, F.J.; Fafián Labora, Juan Antonio; Arufe, M.C. (MDPI, 2021-03-25)[Abstract] Mesenchymal stem cells have an important potential in the treatment of age-related diseases. In the last years, small extracellular vesicles derived from these stem cells have been proposed as cell-free ... -
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
Morente-López, Miriam; Mato-Basalo, Rocío; Lucio-Gallego, Sergio; Silva-Fernández, Lucía; González-Rodríguez, Alba; De-Toro, Javier; Fafián Labora, Juan Antonio; Arufe, M.C. (Springer, 2022-10-20)[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...