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Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K
dc.contributor.author | Urda, Carlos | |
dc.contributor.author | Fernández, Rogelio | |
dc.contributor.author | Rodríguez, Jaime | |
dc.contributor.author | Pérez, Marta | |
dc.contributor.author | Jiménez, Carlos | |
dc.contributor.author | Cuevas, Carmen | |
dc.date.accessioned | 2017-09-26T13:24:15Z | |
dc.date.available | 2017-09-26T13:24:15Z | |
dc.date.issued | 2017-07-01 | |
dc.identifier.citation | Urda, C.; Fernández, R.; Rodríguez, J.; Pérez, M.; Jiménez, C.; Cuevas, C. Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K. Mar. Drugs 2017, 15, 209. | es_ES |
dc.identifier.issn | 1660-3397 | |
dc.identifier.uri | http://hdl.handle.net/2183/19540 | |
dc.description.abstract | [Abstract] Two novel oxazole-thiazole containing cyclic hexapeptides, bistratamides M (1) and N (2) have been isolated from the marine ascidian Lissoclinum bistratum (L. bistratum) collected in Raja Ampat (Papua Bar, Indonesia). The planar structure of 1 and 2 was assigned on the basis of extensive 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configuration of the amino acid residues in 1 and 2 was determined by the application of the Marfey’s and advanced Marfey’s methods after ozonolysis followed by acid-catalyzed hydrolysis. The interaction between zinc (II) and the naturally known bistratamide K (3), a cyclic hexapeptide isolated from a different specimen of Lissoclinum bistratum, was monitored by 1H and 13C NMR. The results obtained are consistent with the proposal that these peptides are biosynthesized for binding to metal ions. Compounds 1 and 2 display moderate cytotoxicity against four human tumor cell lines with GI50 values in the micromolar range. | es_ES |
dc.description.sponsorship | Ministerio de Economía, Industria y Competitividad; RTC-2016-4611-1 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Dixital Publishing Institute | es_ES |
dc.relation.uri | https://doi.org/10.3390/md15070209 | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Cytotoxic | es_ES |
dc.subject | Sponge | es_ES |
dc.subject | Lissoclinum bistratum | es_ES |
dc.subject | Cyclic hexapeptides | es_ES |
dc.subject | Bistratamides | es_ES |
dc.subject | Zn complex | es_ES |
dc.title | Bistratamides M and N, Oxazole-Thiazole Containing Cyclic Hexapeptides Isolated from Lissoclinum bistratum Interaction of Zinc (II) with Bistratamide K | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Marine Drugs | es_ES |
UDC.volume | 15 | es_ES |
UDC.issue | 7 | es_ES |
UDC.startPage | 209 | es_ES |