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Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect
(Bentham Science, 2009)
[Abstract] The first “growth hormone secretagogues” (GHSs) were discovered by Bowers et al. in 1977. In 1996 the GHSs receptor (GHS-R 1a) was cloned. The endogenous ligand for this receptor, ghrelin, was not identified ...
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
(Oxford para Endocrine Society, 2009-10-01)
[Abstract] GH plays a major role in the regulation of lipid metabolism and alterations in GH axis elicit major changes in fat distribution and mobilization. For example, in patients with GH deficiency (GHD) or in mice ...
Ghrelin in obesity, physiological and pharmacological considerations
(Bentham, 2013-04)
[Abstract] The aim of this review is to summarize the physiological and pharmacological aspects of ghrelin. Obesity can be defined as an excess of body fat and is associated with significant disturbances in metabolic and ...
Sexual dimorphism on growth hormone secretion after oral glucose administration
(Thieme, 2012-02-16)
[Abstract] Sexual dimorphism of GH secretion is unclear in humans. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Our aim was to study fasting GH ...
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
(Elsevier, 2011)
[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese women
(Thieme, 2011-06-10)
[Abstract] The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Ghrelin is a peptide that ...
Influence of ghrelin and growth hormone deficiency on AMP-activated protein kinase and hypothalamic lipid metabolism
(Wiley, 2010-03-08)
[Abstract] Current evidence demonstrates that the stomach-derived hormone ghrelin, a potent growth hormone (GH) secretagogue, promotes feeding through a mechanism involving the short-term activation of hypothalamic ...
Fasting and postprandial plasma ghrelin levels are decreased in patients with liver failure previous to liver transplantation
(Spirnger, 2009-04-11)
[Abstract] Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Concentrations of ghrelin are controversial in liver ...