Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial
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Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical TrialAutor(es)
Fecha
2019Cita bibliográfica
Garrido-Castells, X.; Becerro-de-Bengoa-Vallejo, R.; Calvo-Lobo, C.; Losa-Iglesias, M.E.; Palomo-López, P.; Navarro-Flores, E.; López-López, D. Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial. J. Clin. Med. 2019, 8, 1552.
Resumen
[Abstract] : Background: Leukocyte and platelet-rich fibrin (L-PRF) may be considered a co-adjuvant
intervention that may play a key role in blood coagulation and tissue repair after nail surgeries.
The aim of this study was to determine the e ectiveness of L-PRF versus nitrofurazone on the
post-surgical bleeding and wound cicatrization period in patients with bilateral onychocryptosis
during surgeries of chemical matrixectomies with 88% phenol solution. Methods: A randomized
single-blind clinical trial was registered with the European Clinical Trials Database (EudraCT) with
identification number 2016-002048-18. Twenty healthy participants with bilateral onychocryptosis
(n = 40) were recruited and bilaterally received both protocols for both halluces. Patients with a
mean age mean of 45.55 12.19 years attended a specialized foot and ankle surgery clinic. Both
halluces of each patient were randomized and allocated to receive L-PRF (experimental group; n = 20
halluces) or nitrofurazone (control group; n = 20 halluces) interventions in conjunction with surgery
of chemical matrixectomies with 88% phenol solution for bilateral ingrown of toenail border (medial
and lateral). Patients were blinded to their intervention in each hallux. The primary outcome
measurement was post-surgical bleeding. The secondary outcome measurements were post-surgical
pain intensity, inflammation, infection, analgesic intake, and wound cicatrization period. Results:
Statistically significant di erences (p < 0.001) were found between both groups showing a reduction
for wound cicatrization period and post-surgical bleeding for the L-PRF intervention with respect
to nitrofurazone treatment. The rest of the outcome measurements did not show any statistically
significant di erences (p > 0.05). Conclusions: L-PRF rather than nitrofurazone in conjunction with
chemical matrixectomies performed with 88% phenol solution reduced the wound cicatrization period
and bleeding after nail surgery. Thus, L-PRF may be considered a first-line co-adjuvant intervention
for patients who su er from nail problems, such as onychocryptosis, that require surgical procedures
Palabras clave
Inflammation
Nail diseases
Pain
Platelet rich plasma
Surgery
Nail diseases
Pain
Platelet rich plasma
Surgery
Versión del editor
Derechos
Atribución 4.0 España
ISSN
2077-0383