Vasomotion and Neurovascular Coupling in the Visual Thalamus In Vivo
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Vasomotion and Neurovascular Coupling in the Visual Thalamus In VivoFecha
2011-12-09Cita bibliográfica
Rivadulla C, Labra C de, Grieve KL, Cudeiro J. Vasomotion and Neurovascular Coupling in the Visual Thalamus "In Vivo". PLoS ONE. 2011;6(12):e28476
Resumen
[Abstract] Spontaneous contraction and relaxation of arteries (and in some instances venules) has been termed vasomotion and has
been observed in an extensive variety of tissues and species. However, its functions and underlying mechanisms are still
under discussion. We demonstrate that in vivo spectrophotometry, measured simultaneously with extracellular recordings
at the same locations in the visual thalamus of the cat, reveals vasomotion, measured as an oscillation (0.14hz) in the
recorded oxyhemoglobin (OxyHb) signal, which appears spontaneously in the microcirculation and can last for periods of
hours. During some non-oscillatory periods, maintained sensory stimulation evokes vasomotion lasting ,30s, resembling an
adaptive vascular phenomenon. This oscillation in the oxyhaemoblobin signal is sensitive to pharmacological manipulation:
it is inducible by chloralose anaesthesia and it can be temporarily blocked by systemic administration of adrenaline or
acetylcholine (ACh). During these oscillatory periods, neurovascular coupling (i.e. the relationship between local neural
activity and the rate of blood supply to that location) appears significantly altered. This raises important questions with
regard to the interpretation of results from studies currently dependent upon a linear relationship between neural activity
and blood flow, such as neuroimaging.
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