Functional two-way analysis of variance and bootstrap methods for neural synchrony analysis
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Functional two-way analysis of variance and bootstrap methods for neural synchrony analysisAutor(es)
Fecha
2014-08-12Cita bibliográfica
González Montoro AM, Cao R, Espinosa N, Cudeiro J, Mariño J. Functional two-way analysis of variance and bootstrap methods for neural synchrony analysis. BMC Neurosci. 2014;15:96
Resumen
[Abstract] Background: Pairwise association between neurons is a key feature in understanding neural coding. Statistical
neuroscience provides tools to estimate and assess these associations. In the mammalian brain, activating ascending
pathways arise from neuronal nuclei located at the brainstem and at the basal forebrain that regulate the transition
between sleep and awake neuronal firing modes in extensive regions of the cerebral cortex, including the primary
visual cortex, where neurons are known to be selective for the orientation of a given stimulus. In this paper, the
estimation of neural synchrony as a function of time is studied in data obtained from anesthetized cats. A functional
data analysis of variance model is proposed. Bootstrap statistical tests are introduced in this context; they are useful
tools for the study of differences in synchrony strength regarding 1) transition between different states (anesthesia
and awake), and 2) affinity given by orientation selectivity.
Results: An analysis of variance model for functional data is proposed for neural synchrony curves, estimated with a
cross-correlation based method. Dependence arising from the experimental setting needs to be accounted for.
Bootstrap tests allow the identification of differences between experimental conditions (modes of activity) and
between pairs of neurons formed by cells with different affinities given by their preferred orientations. In our test case,
interactions between experimental conditions and preferred orientations are not statistically significant.
Conclusions: The results reflect the effect of different experimental conditions, as well as the affinity regarding
orientation selectivity in neural synchrony and, therefore, in neural coding. A cross-correlation based method is
proposed that works well under low firing activity. Functional data statistical tools produce results that are useful in
this context. Dependence is shown to be necessary to account for, and bootstrap tests are an appropriate method
with which to do so.
Palabras clave
Cross-correlation analysis
Bootstrap
Spike-trains
Dependence
Low firing-rate
Functional data
Bootstrap
Spike-trains
Dependence
Low firing-rate
Functional data
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Creative Commons Attribution 2.0 (CC-BY 2.0)