• A Meta-Analysis of Genome-Wide Association Studies Identifies Novel Variants Associated with Osteoarthritis of the Hip 

      Evangelou, Evangelos; Kerkhof, Hanneke J.; Styrkarsdottir, Unnur; Ntzani, Evangelia E.; Bos, Steffan D.; Esko, Tonu; Evans, Daniel S.; Metrustry, Sarah; Panoutsopoulou, Kalliope; Ramos, Yolande F. M.; Thorleifsson, Gudmar; Tsilidis, Konstantinos K.; Arden, Nigel; Aslam, Nadim; Bellamy, Nicholas; Birrell, Fraser; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Day-Williams, Aaaron G.; Deloukas, Panos; Doherty, Michael; Engström, Gunnar; Helgadottir, Hafdis T.; Hofman, Albert; Ingvarsson, Thorvaldur; Jonsson, Helgi; Keis, Aime; Keurentjes, J. Christiaan; Kloppenburg, Margreet; Lind, Penelope A.; McCaskie, Andrew; Martin, Nicholas G.; Milani, Lili; Montgomery, Grant W.; Nelissen, Rob G.H.H.; Nevitt, Michael C.; Nilsson, Peter M.; Ollier, William E.R.; Parimi, Neeta; Rai, Ashok; Ralston, Stuart H.; Reed, Mike R.; Riancho, José A.; Rivadeneira, Fernando; Rodríguez-Fontenla, Cristina; Southam, Lorraine; Thorsteindottir, Unnur; Tsezou, Aspasia; Wallis, Gillian A.; Wilkinson, J. Mark; González, Antonio; Lane, Nancy E.; Lohmander, L. Stefan; Loughlin, John; Metspalu, Andres; Uitterlinden, André G.; Jonsdottir, Ingileif; Stefansson, Kari; Slagboom, P. Eline; Zeggini, Eleftheria; Meulebelt, Ingrid; Ionnidis, John P.A.; Spector, Tim D.; van Meurs, Joyce B.J.; Valdes, Ana M. (BMJ, 2013-08-29)
      [Abstract] OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies ...
    • Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies 

      Rodríguez-Fontenla, Cristina; Calaza, Manuel; Evangelou, Evangelos; Valdés, Ana M.; Arden, Nigel; Blanco García, Francisco J; Carr, Andrew; Chapman, Kay; Deloukas, Panos; Doherty, Michael; Esko, Tonu; Garcés Aletá, Carlos M.; Gómez-Reino Carnota, Juan J.; Helgadottir, Hafids; Hofman, Albert; Jonsdottir, Ingilef; Kerkhof, Henneke J.M.; Kloppenburg, Margreet; McCaskie, Andrew; Ntzani, Evangelia E.; Ollier, William E.R.; Oreiro, Natividad; Panoutsopoulo, Kalliope; Ralston, Stuart H.; Ramos, Yolande F. M.; Riancho, José A.; Rivadeneira, Fernando; Slagboom, Eline; Styrkarsdottir, Unnur; Thorsteindottir, Unnur; Thorleifsson, Gudmar; Tsezou, Aspasia; Uitterlinden, André G.; Wallis, Gillian A.; Wilkinson, J. Mark; Zhai, Yanyan; Felson, David T.; Ioannidis, John P.A.; Loughlin, John; Metspalu, Andres; Meulenbelt, Ingrid; Stefansson, Kari; van Meurs, Joyce B.; Zeggini, Eleftheria; Spector, Timothy D.; González, Antonio (Wiley, 2013-12-10)
      [Abstract] Objective: To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods: A total of 199 ...
    • Translation of clinical problems in osteoarthritis into pathophysiological research goals 

      van der Kraan, Peter M.; Berenbaum, Francis; Blanco García, Francisco J; De Bari, Cosimo; Lafeber, Floris; Hauge, Ellen; Higginbottom, Adele; Ioan-Facsinay, Andreea; Loughlin, John; Meulenbelt, Ingrid; Moilanen, Eeva; Pitsilidou, Irene; Tsezou, Aspasia; van Meurs, Joyce; Vincent, Tonia; Wittoek, Ruth; Lories, Rik (BMJ, 2016-05-26)
      [Abstract] Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent ...