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Colorectal cancer recurrence and its impact on survival after curative surgery: an analysis based on multistate models
dc.contributor.author | Balboa-Barreiro, Vanesa | |
dc.contributor.author | Pértega-Díaz, Sonia | |
dc.contributor.author | García-Rodríguez, Teresa | |
dc.contributor.author | González-Martín, Cristina | |
dc.contributor.author | Pardeiro-Pértega, Remedios | |
dc.contributor.author | Yáñez-González-Dopeso, Loreto | |
dc.contributor.author | Seoane-Pillado, Teresa | |
dc.date.accessioned | 2024-01-10T08:06:30Z | |
dc.date.available | 2024-01-10T08:06:30Z | |
dc.date.issued | 2023-12-11 | |
dc.identifier.citation | Balboa-Barreiro V, Pértega-Díaz S, García-Rodríguez T, González-Martín C, Pardeiro-Pértega R, Yáñez-González-Dopeso L, Seoane-Pillado T. Colorectal cancer recurrence and its impact on survival after curative surgery: An analysis based on multistate models. Dig Liver Dis. 2023 Dec 11:S1590-8658(23)01074-5. | es_ES |
dc.identifier.issn | 1590-8658 | |
dc.identifier.uri | http://hdl.handle.net/2183/34786 | |
dc.description.abstract | [Abstract] Aim: To investigate the usefulness of multistate models (MSM) for determining colorectal cancer (CRC) recurrence rate, to analyse the effect of different factors on tumour recurrence and death, and to assess the impact of recurrence for CRC prognosis. Methods: Observational follow-up study of incident CRC cases disease-free after curative resection in 2006-2013 (n = 994). Recurrence and mortality were analyzed with MSM, as well as covariate effects on transition probabilities. Results: Cumulative incidence of recurrence at 60 months was 13.7%. Five years after surgery, 70.3% of patients were alive and recurrence-free, and 8.4% were alive after recurrence. Recurrence has a negative impact on prognosis, with 5-year CRC-related mortality increasing from 3.8% for those who are recurrence-free 1-year after surgery to 33.6% for those with a recurrence. Advanced stage increases recurrence risk (HR = 1.53) and CRC-related mortality after recurrence (HR = 2.35). CRC-related death was associated with age in recurrence-free patients, and with comorbidity after recurrence. As expected, age≥75 years was a risk factor for non-CRC-related death with (HR = 7.76) or without recurrence (HR = 4.26), while its effect on recurrence risk was not demonstrated. Conclusions: MSM allows detailed analysis of recurrence and mortality in CRC. Recurrence has a negative impact on prognosis. Advanced stage was a determining factor for recurrence and CRC-death after recurrence. | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI18%2F01676/ES/CARACTERIZACIÓN DE GRANDES SUPERIVIENTES EN CANCER COLORRECTAL: APLICACIÓN DE MODELOS DE CURACIÓN PARA LA ESTIMACIÓN DE LA SUPERVIVENCIA A LARGO PLAZO | es_ES |
dc.description.sponsorship | The cohort in which the study was based was recruited within the framework of a multicenter project who received two other grants from the Ministry of Science and Innovation, Carlos III Institute, Healthcare Research Fund (PI051075 and PS09/0066375) | es_ES |
dc.description.sponsorship | Xunta de Galicia; 08CSA073916PR | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | https://doi.org/10.1016/j.dld.2023.11.041 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC-BY-NC-ND 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Colorectal neoplasms | es_ES |
dc.subject | Models, statistical | es_ES |
dc.subject | Neoplam recurrence | es_ES |
dc.subject | Prognosis | es_ES |
dc.title | Colorectal cancer recurrence and its impact on survival after curative surgery: an analysis based on multistate models | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Digestive and Liver Disease | es_ES |
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