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Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway
(BioMed Central, 2012-09-01)
[Abstract]
Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
Circulating microRNAs: molecular microsensors in gastrointestinal cancer
(MPDI, 2012-07-09)
[Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
Differential feedback modulation of center and surround mechanisms in parvocellular cells in the visual thalamus
(Society of Neuroscience, 2012-11-07)
[Abstract] Many cells in both the central visual system and other sensory systems exhibit a center surround organization in their receptive field, where the response to a centrally placed stimulus is modified when a ...
Mitochondrial haplogroups H and J: risk and protective factors for ischemic cardiomyopathy
(PLoS, 2012-08-28)
[Abstract] Background. Since mitochondria are the principal source of reactive oxygen species (ROS), these organelles may play an important role in ischemic cardiomyopathy (IC) development. The mitochondrial genome may ...
miR-203 regulates cell proliferation through Its influence on Hakai expression
(PLoS, 2012-12-20)
Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...
Biological influence of Hakai in cancer: a 10-year review
(Springer, 2012-02-19)
[Abstract] In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the ...
Crossing paths in Human Renal Cell Carcinoma (hRCC)
(MDPI, 2012-10-05)
[Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...
Mitochondrial haplogroups define two phenotypes of osteoarthritis
(Frontiers, 2012-05-11)
[Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA).
Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...
Validity of the finger tapping test in Parkinson’s disease, elderly and young healthy subjects: is there a role for central fatigue?
(Elsevier, 2012-05-03)
[Abstract] Objective: The main goal of this work is to evaluate the validity of the finger tapping test (FT) to detect alterations in rhythm formation.
Methods: We use FT to study the alterations in motor rhythm in three ...
Antagonist muscle co-activation during straight walking and its relation to kinematics: Insight from young, elderly and Parkinson's disease
(Elsevier, 2012-03-21)
[Abstract] Increased antagonist muscle co-activation of the lower limb during walking seems to be an
adaptive process to the physiological changes of aging, in order to gain joint stability. In the
healthy subjects this ...