• Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3 

      Borghesan, Michela; Fafián Labora, Juan Antonio; Eleftheriadou, Olga; Carpintero-Fernández, Paula; Paez-Ribes, Marta; Vizcay-Barrena, Gema; Swisa, Avital; Kolodkin-Gal, Dror; Ximénez-Embún, Pilar; Lowe, Robert; Martín-Martín, Belén; Peinado, Héctor; Muñoz, Javier; Fleck, Roland A.; Dor, Yuval; Ben-Porath, Ittai; Vossenkamper, Anna; Muñoz-Espin, Daniel; O’Loghlen, Ana (Cell Press, 2019-06-25)
      [Abstract] Senescence is a cellular phenotype present in health and disease, characterized by a stable cell-cycle arrest and an inflammatory response called senescence-associated secretory phenotype (SASP). The SASP is ...
    • Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage 

      Fafián Labora, Juan Antonio; Rodríguez-Navarro, José Antonio; O’Loghlen, Ana (Elsevier, 2020-07-07)
      [Abstract] Aging is a process of cellular and tissue dysfunction characterized by different hallmarks, including cellular senescence. However, there is proof that certain features of aging and senescence can be ameliorated. ...