Changes in Visual Responses in the Feline dLGN: Selective Thalamic Suppression Induced by Transcranial Magnetic Stimulation of V1
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Changes in Visual Responses in the Feline dLGN: Selective Thalamic Suppression Induced by Transcranial Magnetic Stimulation of V1Autor(es)
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2006-08-14Cita bibliográfica
Labra C, Rivadulla C, Grieve K, Mariño J, Espinosa N, Cudeiro J. Changes in Visual Responses in the Feline dLGN: Selective Thalamic Suppression Induced by Transcranial Magnetic Stimulation of V1. Cereb Cortex. 2007;17(6):1376-1385
Resumo
[Abstract] Transcranial magnetic stimulation (TMS) of the cortex can modify activity noninvasively and produce either excitatory or inhibitory effects, depending on stimulus parameters. Here we demonstrate controlled inhibitory effects on the large corticogeniculate feedback pathway from primary visual cortex to cells of the dorsal lateral geniculate nucleus (dLGN) that are focal and reversible—induced by either single pulses or trains of pulses of TMS. These effects selectively suppress the sustained component of responses to flashed spots or moving grating stimuli and are the result of loss of spikes fired in tonic mode, whereas the number of spikes fired in bursts remain the same. We conclude that acute inactivation of the corticogeniculate downflow selectively affects the tonic mode. We found no evidence to suggest that cortical inactivation increased burst frequency.
Palabras chave
Burst
Corticothalamic
TMS
Corticothalamic
TMS
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This is a pre-copyedited, author-produced PDF of an article accepted for publication in "Cerebral Cortex" following peer review. The version of the record is avaliable online at oxfordjournals.org