Listar por autor "Rocha Loureda, Beatriz"

Mostrando ítems 1-7 de 7

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers 

      Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
      [Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...

    • Identificación de nuevos biomarcadores de la condrogénesis de células madre mesenquimales de pacientes con artrosis mediante técnicas proteómicas 

      Rocha Loureda, Beatriz (2015)
      [Resumen]La capacidad de diferenciación de las células madre mesenquimales (MSCs) hacia condrocitos, en un proceso conocido como condrogénesis, concede a estas células un gran potencial terapéutico para la reparación de ...

    • Identification of a Distinct Lipidomic Profile in the Osteoarthritic Synovial Membrane by Mass Spectrometry Imaging 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Ruiz-Romero, Cristina; Paine, Martin R.L.; Cañete, Juan D.; Heeren, Ron M.A.; Blanco García, Francisco J (Elsevier, 2021-05)
      [Abstract] Objective: Synovial inflammation is one of the most characteristic events in different types of arthritis, including Osteoarthritis (OA). Emerging evidence also suggests the involvement of lipids in the regulation ...

    • Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
      [Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...

    • Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis 

      Blanco García, Francisco J; Camacho Encina, María; González-Rodríguez, Lucía; Rego-Pérez, Ignacio; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Picchi, Florencia; Silva-Díaz, María T.; Herrero, Marta; Martínez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina (Sage, 2019-08-24)
      [Abstract] Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin ...

    • Targeted Phospholipidomic Analysis of Synovial Fluid as a Tool for Osteoarthritis Deep Phenotyping 

      Rocha Loureda, Beatriz; Illiano, Anna; Calamia, Valentina; Pinto, Gabriella; Amoresano, Angela; Ruiz-Romero, Cristina; Blanco García, Francisco J (Elsevier, 2021-10-20)
      [Abstract] Objective. The aim of this study was to carry out a targeted phospholipidomic analysis on synovial fluid (SF) from patients with different grades of osteoarthritis (OA) and controls, in order to search for ...