Listar por autor "Antón-Aparicio, Luis M."

Mostrando ítems 21-40 de 49

    • Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Reboredo, Margarita; Lorenzo-Patiño, María J.; Iglesias-Díaz, Pilar; Haz, Mar; Díaz-Prado, Silvia; Medina, Vanessa; Santamarina, Isabel; Pértega-Díaz, Sonia; Figueroa, Angélica; Antón-Aparicio, Luis M. (MDPI, 2012-04-05)
      [Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...

    • Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis 

      Capdevila, Jaume; Sevilla, Isabel; Alonso, Vicente; Antón-Aparicio, Luis M.; Jiménez Fonseca, Paula; Grande, Enrique; Reina, Juan José; Manzano, José Luis; Alonso Lájara, Juan Domingo; Barriuso, Jorge; Castellano, Daniel; Medina, Javier; López, Carlos; Segura, Ángel; Carrera, Sergio; Crespo, Guillermo; Fuster, José; Munarriz, Javier; García Alfonso, Pilar (BioMed Central, 2015-07-04)
      [Abstract] Background. Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for the treatment of patients with neuroendocrine ...

    • Experience with Sunitinib in metastatic renal cell carcinoma (mRCC) patients: pooled analysis from 3 Spanish observational prospective studies 

      Castellano, Daniel; Maroto, José Pablo; Espinosa, Enrique; Grande, Enrique; Bolós Fernández, Victoria; Llinares, Julia; Esteban, Emilio; González del Alba, Aránzazu; Climent, Miguel Ángel; Arranz, José Ángel; Méndez, María José; Fernández Parra, Eva; Antón-Aparicio, Luis M.; Bayona, Cristina; Gallegos, Isabel; Gallardo, Enrique; Samaniego, Luz; García Donas, Jesús (Taylor & Francis, 2017-08-28)
      [Abstract] Background: A pivotal, randomized, phase III trial demonstrated a statistically significant superiority of sunitinib over interferon-α in metastatic renal cell carcinoma (mRCC) patients. Objective: To evaluate ...

    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...

    • Fructose transporter Glut5 expression in clear renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valbuena Ruvira, L.; García Campelo, R.; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Bolós Fernández, Victoria; Santamarina, Isabel; Antón-Aparicio, Luis M. (Spandidos, 2010-12-10)
      [Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous ...

    • Glucose transporter expression and the potential role of fructose in renal cell carcinoma: a correlation with pathological parameters 

      Antón-Aparicio, Luis M.; Medina Villaamil, Vanessa; Blanco, Moisés; Valbuena Ruvira, L.; Rois, José Manuel; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Bolós Fernández, Victoria; Grande Pulido, Enrique (Spandidos, 2010-07-01)
      [Abstract] All mammalian cells contain one or more members of the facilitative glucose transporter (GLUT) gene family. Glucose transporter membrane proteins (GLUT) regulate the movement of glucose between the extracellular ...

    • Hakai reduces cell-substratum adhesion and increases epithelial cell invasion 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Antón-Aparicio, Luis M.; Figueroa, Angélica (BioMed Central, 2011-11-03)
      [Abstract] Background. The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the ...

    • MicroARN circulantes en sangre de pacientes con cáncer de próstata 

      Medina Villaamil, Vanessa; Martínez-Breijo, S.; Portela-Pereira, P.; Quindós-Varela, María; Santamarina, Isabel; Antón-Aparicio, Luis M.; Gómez Veiga, Francisco (Elsevier, 2014)
      [Resumen] Introducción. Los microARN (miARN) son ARN reguladores de pequeño tamaño que no codifican para proteínas. La detección de células tumorales circulantes (CTC) proporcionaría información diagnóstica y pronóstica ...

    • miR-203 regulates cell proliferation through Its influence on Hakai expression 

      Abella Cajigal, Vanessa; Valladares-Ayerbes, Manuel; Rodríguez, Teresa; Haz, Mar; Blanco, Moisés; Tarrío, Nuria; Iglesias, Pilar; Antón-Aparicio, Luis M.; Figueroa, Angélica (PLoS, 2012-12-20)
      Gene expression is potently regulated through the action of microRNAs (miRNAs). Here, we present evidence of a miRNA regulating Hakai protein. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational ...

    • Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valladares-Ayerbes, Manuel; Santamarina, Isabel; Antón-Aparicio, Luis M. (BioMed Central, 2012-09-01)
      [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...

    • New insights into molecular mechanisms of sunitinib-associated side effects 

      Aparicio Gallego, Guadalupe; Blanco, Moisés; Figueroa, Angélica; García-Campelo, Rosario; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Antón-Aparicio, Luis M. (American Association for Cancer Research, 2011-12)
      [Abstract] The introduction of targeted therapy represents a major advance in the treatment of tumor progression. Targeted agents are a novel therapeutic approach developed to disrupt different cellular signaling pathways. ...

    • Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma 

      Puente, Javier; Lainez, Nuria; Dueñas, Marta; Méndez-Vidal, María José; Esteban, Emilio; Castellano, Daniel; Martínez-Fernández, Mónica; Basterretxea, Laura; Juan-Fita, María José; Antón-Aparicio, Luis M.; León, Luis; Lambea, Julio; Pérez-Valderrama, Begoña; Vázquez, Sergio; Suárez, Cristina; García del Muro, Xavier; Gallardo, Enrique; Maroto, José Pablo; Samaniego, M. Luz; Suárez-Paniagua, Beatriz; Sanz, Julián; Paramio, Jesús M. (Impact Journals, 2017-03-23)
      [Abstract] Background: Several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further ...

    • Origin of renal cell carcinomas 

      Valladares-Ayerbes, Manuel; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Antón-Aparicio, Luis M. (Springer, 2008-11-28)
      [Abstract] Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the “two hits” of Knudson’s hypothesis, which has proved true for ...

    • Phase II Randomized Study of Figitumumab plus Docetaxel and Docetaxel Alone with Crossover for Metastatic Castration-Resistant Prostate Cancer 

      De Bono, Johann S.; Piulats, Josep María; Pandha, Hardev S.; Petrylak, Daniel P.; Saad, Fred; Antón-Aparicio, Luis M.; Sandhu, Shahneen K.; Fong, Peter; Gillessen, Silke; Hudes, Gary R.; Wang, Tao; Scranton, Judith; Pollak, Michael N. (American Association for Cancer Research, 2014-02-17)
      [Abstract] PURPOSE: Figitumumab is a human IgG2 monoclonal antibody targeting insulin-like growth factor 1 receptor (IGF-1R), with antitumor activity in prostate cancer. This phase II trial randomized chemotherapy-naïve ...

    • Posttranscriptional regulation by RNA-binding proteins during epithelial-to-mesenchymal transition 

      Antón-Aparicio, Luis M.; Abella Cajigal, Vanessa; Valladares-Ayerbes, Manuel; Figueroa, Angélica (Springer, 2013-05-29)
      [Abstract] Epithelial-to-mesenchymal transition (EMT), one of the crucial steps for carcinoma cells to acquire invasive capacity, results from the disruption of cell–cell contacts and the acquisition of a motile mesenchymal ...

    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...

    • Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Haz, Mar; Medina, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Reboredo, Margarita; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (Spandidos, 2011-07-04)
      [Abstract] The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated ...

    • Prostate cancer and Hedgehog signalling pathway 

      Antón-Aparicio, Luis M.; García Campelo, Rosario; Casinello Espinosa, J.; Valladares-Ayerbes, Manuel; Reboredo, Margarita; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-08-02)
      [Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...

    • Prostate carcinoma and stem cells 

      Antón-Aparicio, Luis M.; Cassinello Espinosa, J.; García Campelo, Rosario; Gómez Veiga, Francisco; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-02)
      [Abstract] Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the ...

    • Radium-223 dichloride: a new paradigm in the treatment of prostate cancer 

      Anido Herranz, Urbano; Fernández Calvo, Ovidio; Afonso Afonso, Francisco Javier; Rodríguez Martínez de Llano, Sofía; Lázaro Quintela, Martín; León Mateos, Luis; Vázquez Estévez, Sergio; Antón-Aparicio, Luis M. (Taylor & Francis, 2015-01-02)
      [Abstract] Radionuclides have been widely used for cancer treatment. Recently, new research about radium-223 dichloride has been conducted in prostate cancer, which reveals that it is the first radiopharmaceutical to ...