Listar por autor "Díaz-Prado, Silvia"

Mostrando ítems 41-60 de 67

    • Human amniotic membrane: a potential tissue and cell source for cell therapy and regenerative medicine 

      Díaz-Prado, Silvia; Muíños-López, Emma; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Springer, 2013)
      [Abstract] The human amniotic membrane (HAM) is the innermost membrane surrounding the fetus. HAM is a highly abundant and readily available tissue that is becoming appreciated as an alternative to adult bone marrow ...

    • Human amniotic mesenchymal stromal cells as favorable source for cartilage repair 

      Muiños-López, Emma; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Mary Ann Liebert, 2017-01-10)
      [Abstract] Introduction: Localized trauma-derived breakdown of the hyaline articular cartilage may progress toward osteoarthritis, a degenerative condition characterized by total loss of articular cartilage and joint ...

    • Human cartilage engineering in an in vitro repair model using collagen scaffolds and mesenchymal stromal cells 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Ivyspring, 2017-09-28)
      [Abstract] The purpose of this study was to investigate cartilage repair of in vitro lesion models using human bone marrow mesenchymal stromal cells (hBMSCs) with different collagen (Col) scaffolds. Lesions were made ...

    • Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview 

      Carballo-Pedrares, Natalia; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia; Rey-Rico, Ana (MDPI, 2020-08-10)
      [Abstract] Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders ...

    • Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features 

      Piñeiro-Ramil, María; Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Rodríguez-Fernández, Silvia; Hermida Gómez, Tamara; Blanco García, Francisco J; Fuentes Boquete, Isaac Manuel; Díaz-Prado, Silvia (Hindawi, 2020-06-16)
      [Abstract] Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral ...

    • Induced pluripotent stem cells for cartilage repair: current status and future perspectives 

      Castro Viñuelas, Rocío; Sanjurjo-Rodríguez, Clara; Piñeiro-Ramil, María; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (AO Research Institute Davos, 2018-09-11)
      [Abstract] The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells ...

    • Isolation and characterization of mesenchymal stem cells from human amniotic membrane 

      Díaz-Prado, Silvia; Muíños-López, Emma; Hermida Gómez, Tamara; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Mary Ann Liebert, 2011-01-04)
      [Abstract] Introduction: The human amniotic membrane is a highly abundant and readily available tissue that may be useful for regenerative medicine and cell therapy. Aim: To compare two previously published protocols for ...

    • Long-term effects of hydrogen sulfide on the anabolic-catabolic balance of articular cartilage in vitro 

      Vela-Anero, Á.; Hermida Gómez, Tamara; Gato Calvo, Lucía; Vaamonde-García, Carlos; Díaz-Prado, Silvia; Meijide-Faílde, Rosa; Blanco García, Francisco J; Burguera, Elena F. (Elsevier, 2017-08-15)
      [Abstract] Healthy cartilage maintenance relies on an equilibrium among the anabolic and catabolic processes in chondrocytes. With the onset of osteoarthritis (OA), increased interleukin (IL)-1β levels induce an inhibition ...

    • Mesenchymal stem cell therapy in traumatic spinal cord injury: a systematic review 

      Montoto-Meijide, Rodrigo; Meijide-Faílde, Rosa; Díaz-Prado, Silvia; Montoto Marqués, Antonio (MDPI, 2023-07-20)
      [Abstract] Recovery from a traumatic spinal cord injury (TSCI) is challenging due to the limited regenerative capacity of the central nervous system to restore cells, myelin, and neural connections. Cell therapy, particularly ...

    • Mesenchymal stem cells from human amniotic membrane 

      Sanjurjo-Rodríguez, Clara; Díaz-Prado, Silvia; Hermida-Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Blanco García, Francisco J (Springer, 2014)
      [Abstract] The human amnion or amniotic membrane (HAM) has emerged as a novel and alternative source of stem cells. This tissue presents a reservoir of two types of stem cells from different embryological origins: human ...

    • Molecular profile and cellular characterization of human bone marrow mesenchymal stem cells: donor influence on chondrogenesis 

      Cicione, Claudia; Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Blanco García, Francisco J (Elsevier, 2010)
      [Abstract] Background. The use of autologous or allogenic stem cells has recently been suggested as an alternative therapeutic approach for treatment of cartilage defects. Bone marrow mesenchymal stem cells (BM-MSCs) are ...

    • Multilineage differentiation potential of cells isolated from the human amniotic membrane 

      Díaz-Prado, Silvia; Muiños-López, Emma; Hermida Gómez, Tamara; Rendal Vázquez, María Esther; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Wiley, 2010-11-01)
      [Abstract] The human amniotic membrane (HAM) contains two cell types from different embryological origins. Human amnion epithelial cells (hAECs) are derived from the embryonic ectoderm, while human amnion mesenchymal stromal ...

    • Notch signalling in cancer stem cells 

      Bolós Fernández, Victoria; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Grande Pulido, Enrique (Springer, 2009)
      [Abstract] A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations ...

    • Origin of renal cell carcinomas 

      Valladares-Ayerbes, Manuel; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Antón-Aparicio, Luis M. (Springer, 2008-11-28)
      [Abstract] Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the “two hits” of Knudson’s hypothesis, which has proved true for ...

    • Ovine mesenchymal stromal cells for osteochondral tissue engineering 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J; Díaz-Prado, Silvia (Elsevier, 2017-04)

    • Ovine mesenchymal stromal cells: morphologic, phenotypic and functional characterization for osteochondral tissue engineering 

      Sanjurjo-Rodríguez, Clara; Castro Viñuelas, Rocío; Hermida Gómez, Tamara; Fernández Vázquez, Tania; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Díaz-Prado, Silvia; Blanco García, Francisco J (PLoS ONE, 2017-01-31)
      [Abstract] Introduction. Knowledge of ovine mesenchymal stromal cells (oMSCs) is currently expanding. Tissue engineering combining scaffolding with oMSCs provides promising therapies for the treatment of osteochondral ...

    • Potential use of the human amniotic membrane as a scaffold in human articular cartilage repair 

      Díaz-Prado, Silvia; Rendal Vázquez, María Esther; Muiños-López, Emma; Hermida Gómez, Tamara; Rodríguez-Cabarcos, Margarita; Fuentes Boquete, Isaac Manuel; De-Toro, Javier; Blanco García, Francisco J (Springer, 2010-04-13)
      [Abstract] The human amniotic membrane (HAM) is an abundant and readily obtained tissue that may be an important source of scaffold for transplanted chondrocytes in cartilage regeneration in vivo. To evaluate the potential ...

    • Prostate cancer and Hedgehog signalling pathway 

      Antón-Aparicio, Luis M.; García Campelo, Rosario; Casinello Espinosa, J.; Valladares-Ayerbes, Manuel; Reboredo, Margarita; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-08-02)
      [Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...

    • Prostate carcinoma and stem cells 

      Antón-Aparicio, Luis M.; Cassinello Espinosa, J.; García Campelo, Rosario; Gómez Veiga, Francisco; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-02)
      [Abstract] Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the ...

    • Quantification of cells expressing mesenchymal stem cell markers in healthy and osteoarthritic synovial membranes 

      Hermida Gómez, Tamara; Fuentes Boquete, Isaac Manuel; Gimeno-Longas, María José; Muiños-López, Emma; Díaz-Prado, Silvia; De-Toro, Javier; Blanco García, Francisco J (Journal of Rheumatology Publishing Company, 2010-11-15)
      [Abstract] Objective. To quantify cells expressing mesenchymal stem cell (MSC) markers in synovial mem- branes from human osteoarthritic (OA) and healthy joints. Methods. Synovial membranes from OA and healthy joints were ...