Deactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavage

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoQuímicaes_ES
UDC.endPage3504es_ES
UDC.grupoInvReactividade Química e Fotorreactividade (REACT!)es_ES
UDC.issue6es_ES
UDC.journalTitleRSC Advanceses_ES
UDC.startPage3500es_ES
UDC.volume12es_ES
dc.contributor.authorRodríguez, Jéssica
dc.contributor.authorPérez-González, Daniel Cibrán
dc.contributor.authorMartínez-Calvo, Miguel
dc.contributor.authorMosquera Mosquera, Jesús
dc.contributor.authorMascareñas, José
dc.date.accessioned2024-10-25T14:37:09Z
dc.date.available2024-10-25T14:37:09Z
dc.date.issued2022-01-26
dc.description.abstract[Abstract]: Herein, we describe an approach for the on-demand disassembly of dimeric peptides using a palladium-mediated cleavage of a designed self-immolative linker. The utility of the strategy is demonstrated for the case of dimeric basic regions of bZIP transcription factors. While the dimer binds designed DNA sequences with good affinities, the peptide–DNA complex can be readily dismounted by addition of palladium reagents that trigger the cleavage of the spacer, and the release of unfunctional monomeric peptides.es_ES
dc.description.sponsorshipWe are thankful for the financial support from the Xunta de Galicia (Centro singular de investigación de Galicia acreditación 2019–2022, ED431G 2019/03) and the European Union (European Regional Development Fund – ERDF). We also thank support given by the Spanish grants PID2019-108624RB-I00, the Xunta de Galicia (grants 2015-CP082, ED431C 2017/19 and 2021-CP054, ED431C-2021/25) and the European Research Council (Advanced Grant No. 340055). MMC and JR thank the MCIN/AEI for their Postdoctoral fellowships (IJCI-2014-19326 and IJC2019-040358-I). Authors would like to thank the use of RIAIDT-USC analytical facilities.es_ES
dc.description.sponsorshipXunta de Galicia; ED431G 2019/03es_ES
dc.description.sponsorshipXunta de Galicia; 2015-CP082es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2017/19es_ES
dc.description.sponsorshipXunta de Galicia; 2021-CP054es_ES
dc.description.sponsorshipXunta de Galicia; ED431C-2021/25es_ES
dc.identifier.citationRSC Adv., 2022, 12, 3500es_ES
dc.identifier.doi10.1039/D1RA09180H
dc.identifier.issn2046-2069
dc.identifier.urihttp://hdl.handle.net/2183/39817
dc.language.isoenges_ES
dc.publisherThe Royal Society of Chemistryes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/340055es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108624RB-I00/ES/HERRAMIENTAS BASADAS EN METALES PARA SU USO EN QUIMICA BIOLOGICA Y BIOMEDICINA. DESARROLLO DE NUEVAS ESTRATEGIAS ANTICANCERes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/IJCI-2014-19326/ES/es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/IJC2019-040358-I/ES/es_ES
dc.relation.urihttps://doi.org/10.1039/D1RA09180Hes_ES
dc.rights© 2022 The Author(s). Published by the Royal Society of Chemistry. This Open Access Article is licensed under a Creative Commons Attribution-Non Commercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/).es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/es/*
dc.subjectDimerses_ES
dc.subjectDNA complexes_ES
dc.subjectDNA-bindinges_ES
dc.subjectPalladiumes_ES
dc.subjectTranscriptiones_ES
dc.subjectBinding peptidees_ES
dc.subjectbZIP transcription factorses_ES
dc.subjectPalladium mediatedes_ES
dc.subjectSelf-immolativees_ES
dc.titleDeactivation of a dimeric DNA-binding peptide through a palladium-mediated self-immolative cleavagees_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
relation.isAuthorOfPublication2df80f03-c849-4521-90f9-aca5e6871e8e
relation.isAuthorOfPublicationd375c056-bd6f-46df-93b5-07e8cf84500a
relation.isAuthorOfPublication.latestForDiscovery2df80f03-c849-4521-90f9-aca5e6871e8e

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