Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system
| UDC.coleccion | Investigación | es_ES |
| UDC.departamento | Fisioterapia, Medicina e Ciencias Biomédicas | es_ES |
| UDC.grupoInv | Investigación en Microbiología (INIBIC) | es_ES |
| UDC.institutoCentro | INIBIC - Instituto de Investigacións Biomédicas de A Coruña | es_ES |
| UDC.issue | 5 | es_ES |
| UDC.journalTitle | Antimicrobial Agents and Chemotherapy | es_ES |
| UDC.volume | 62 | es_ES |
| dc.contributor.author | Fernández-García, Laura | |
| dc.contributor.author | Fernández-Cuenca, Felipe | |
| dc.contributor.author | Blasco, Lucía | |
| dc.contributor.author | López-Rojas, Rafael | |
| dc.contributor.author | Ambroa, Antón | |
| dc.contributor.author | Zamora López, María José | |
| dc.contributor.author | Pascual, Álvaro | |
| dc.contributor.author | Bou, Germán | |
| dc.contributor.author | Tomás, María | |
| dc.date.accessioned | 2025-03-24T11:12:09Z | |
| dc.date.available | 2025-03-24T11:12:09Z | |
| dc.date.issued | 2018-04-26 | |
| dc.description.abstract | [Abstract] The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine. | es_ES |
| dc.description.sponsorship | This study was funded by grants PI13/02390 and PI16/01163, awarded to M.T., and by grant PI11-02046, awarded to F.F.-C., within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011) and cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research—European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI, grants RD12/0015/0010 and RD16/0016/0001), as well as by the Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC). M.T. was financially supported by the Miguel Servet Research Programme (SERGAS and ISCIII). L.F.-G. was financially supported by a predoctoral fellowship from the Xunta de Galicia (GAIN, Axencia de Innovación). | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI13%2F02390/ES/Relación entre Quorum Sensing y mecanismos de resistencia en patógenos nosocomiales. Nuevas Terapias Antivirulentas | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F01163/ES/"Terapia FÁGICA CLÍNICA: Nuevos retos" | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MICINN/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI11%2F02046/ES/Resistencia a biocidas en patógenos gram negativos nosocomiales: bases moleculares e impacto sobre el fitness y la corresistencia a antimicrobianos | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Acción Estratégica de Salud/RD12%2F0015%2F0010/ES/Enfermedades infecciosas | es_ES |
| dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16%2F0016%2F0001/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN PATOLOGÍAS INFECCIOSAS | es_ES |
| dc.identifier.citation | Fernández-García L, Fernandez-Cuenca F, Blasco L, López-Rojas R, Ambroa A, Lopez M, Pascual Á, Bou G, Tomás M. Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00250-18. | es_ES |
| dc.identifier.doi | 10.1128/AAC.00250-18 | |
| dc.identifier.issn | 0066-4804 | |
| dc.identifier.uri | http://hdl.handle.net/2183/41513 | |
| dc.language.iso | eng | es_ES |
| dc.publisher | American Society of Microbiology | es_ES |
| dc.relation.uri | https://doi.org/10.1128/aac.00250-18 | es_ES |
| dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
| dc.rights.accessRights | open access | es_ES |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
| dc.subject | Tolerance | es_ES |
| dc.subject | Persistence | es_ES |
| dc.subject | Chlorhexidine | es_ES |
| dc.subject | Imiperem | es_ES |
| dc.subject | Acinetobacter | es_ES |
| dc.subject | Toxin-antioxin | es_ES |
| dc.title | Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system | es_ES |
| dc.type | journal article | es_ES |
| dc.type.hasVersion | VoR | es_ES |
| dspace.entity.type | Publication | |
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