Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system

Fernández-García, Laura; Fernández-Cuenca, Felipe; Blasco, Lucía; López-Rojas, Rafael; Ambroa, Antón; Zamora López, María José; Pascual, Álvaro; Bou, Germán; Tomás, María

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http://hdl.handle.net/2183/41513

Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system

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Identifiers

URI: http://hdl.handle.net/2183/41513

DOI: 10.1128/AAC.00250-18

Publication date

2018-04-26

Authors

Fernández-García, Laura

Fernández-Cuenca, Felipe

Blasco, Lucía

López-Rojas, Rafael

Ambroa, Antón

Zamora López, María José

Pascual, Álvaro

Bou, Germán

Tomás, María

Bibliographic citation

Fernández-García L, Fernandez-Cuenca F, Blasco L, López-Rojas R, Ambroa A, Lopez M, Pascual Á, Bou G, Tomás M. Relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with AbkAB toxin-antitoxin system. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00250-18.

Abstract

[Abstract] The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.