OXA-207, a Novel OXA-24 Variant With Reduced Catalytic Efficiency Against Carbapenems in Acinetobacter Pittii From Spain
| UDC.coleccion | Investigación | |
| UDC.departamento | Fisioterapia, Medicina e Ciencias Biomédicas | |
| UDC.endPage | 4948 | |
| UDC.grupoInv | Investigación en Microbiología (INIBIC) | |
| UDC.institutoCentro | INIBIC - Instituto de Investigacións Biomédicas de A Coruña | |
| UDC.issue | 8 | |
| UDC.journalTitle | Antimicrobial Agents and Chemotherapy | |
| UDC.startPage | 4944 | |
| UDC.volume | 58 | |
| dc.contributor.author | Cayo, Rodrigo | |
| dc.contributor.author | Merino Carballeira, María | |
| dc.contributor.author | Ruiz del Castillo, Belén | |
| dc.contributor.author | Cano, María E. | |
| dc.contributor.author | García Calvo-Montes, Jorge | |
| dc.contributor.author | Bou, Germán | |
| dc.contributor.author | Martínez-Martínez, Luis | |
| dc.date.accessioned | 2026-09-23T10:27:29Z | |
| dc.date.available | 2026-09-23T10:27:29Z | |
| dc.date.issued | 2014-07-15 | |
| dc.description | Brief report | |
| dc.description.abstract | [Abstract] A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin. | |
| dc.description.sponsorship | This work was partially supported by the Ministerio de Economía y Competitividad, Instituto de Salud Carlos III - cofinanced by the European Development Regional Fund “A way to achieve Europe” ERDF, the Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015), and by the Fondo de Investigación Sanitaria (PI080209, PS09/00687, and PI12/00552). We are grateful to the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), which gave a PDEE grant to R.C. (protocol 4149/08-4). | |
| dc.identifier.citation | Cayô R, Merino M, Ruiz Del Castillo B, Cano ME, Calvo J, Bou G, Martínez-Martínez L. OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain. Antimicrob Agents Chemother. 2014 Aug;58(8):4944-8. | |
| dc.identifier.doi | 10.1128/AAC.02633-13 | |
| dc.identifier.issn | 1098-6596 | |
| dc.identifier.uri | https://hdl.handle.net/2183/49395 | |
| dc.language.iso | eng | |
| dc.publisher | American Society for Microbiology | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//RD12%2F0015%2F0002/ES/Enfermedades infecciosas/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//PS09%2F00687/ES/MECANISMO DE ACCION DE LOS ANTIBIOTICOS EN ACINETOBACTER BAUMANNII Y ESTRES OXIDATIVO: APLICACION AL DIAGNOSTICO RAPIDO DE RESISTENCIAS A ANTIMICROBIANOS/ | |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI12%2F00552/ES/Estudios preclínicos con D-aminoácidos para atenuar la virulencia de Acinetobacter baumannii y otros patógenos multirresistentes: Una nueva estrategia para erradicar una infección/ | |
| dc.relation.uri | https://doi.org/10.1128/AAC.02633-13 | |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.accessRights | open access | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Acinetobacter | |
| dc.subject | Anti-Bacterial Agents | |
| dc.subject | Carbapenems | |
| dc.subject | Oxacillin | |
| dc.subject | beta-Lactamases | |
| dc.title | OXA-207, a Novel OXA-24 Variant With Reduced Catalytic Efficiency Against Carbapenems in Acinetobacter Pittii From Spain | |
| dc.type | journal article | |
| dc.type.hasVersion | AM | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 909e08d1-6ed1-4b99-9e9e-c64eb72e7dea | |
| relation.isAuthorOfPublication.latestForDiscovery | 909e08d1-6ed1-4b99-9e9e-c64eb72e7dea |
Files
Original bundle
1 - 1 of 1