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https://hdl.handle.net/2183/49395

OXA-207, a Novel OXA-24 Variant With Reduced Catalytic Efficiency Against Carbapenems in Acinetobacter Pittii From Spain

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URI: https://hdl.handle.net/2183/49395
DOI: 10.1128/AAC.02633-13

Publication date

2014-07-15

Authors

Cayo, Rodrigo
Merino Carballeira, María
Ruiz del Castillo, Belén
Cano, María E.
García Calvo-Montes, Jorge
Martínez-Martínez, Luis

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Journal Title

Bibliographic citation

Cayô R, Merino M, Ruiz Del Castillo B, Cano ME, Calvo J, Bou G, Martínez-Martínez L. OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain. Antimicrob Agents Chemother. 2014 Aug;58(8):4944-8.

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Academic degree

Abstract

[Abstract] A carbapenem-resistant Acinetobacter pittii strain carrying an OXA-24-like enzyme was isolated in northern Spain in 2008. Sequence analysis confirmed the presence of the novel bla(OXA-207) gene flanked by the site-specific XerC/XerD-like recombination binding sites and showing a unique Gly222Val substitution compared to OXA-24. Cloning and kinetic analysis showed that OXA-207 presents a reduction in the catalytic efficiency against carbapenems and a noticeable increase for oxacillin.

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Keywords

Acinetobacter Anti-Bacterial Agents Carbapenems Oxacillin beta-Lactamases

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https://doi.org/10.1128/AAC.02633-13

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Attribution 4.0 International

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