Individual Telomere Length Decay in Patients With Spondyloarthritis

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UDC.coleccionInvestigación
UDC.departamentoCiencias da Saúde
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicas
UDC.grupoInvEnfermería e Coidados da Saúde (INIBIC)
UDC.grupoInvReumatoloxía (INIBIC)
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruña
UDC.journalTitleMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
UDC.volume765
dc.contributor.authorTamayo, María
dc.contributor.authorPértega-Díaz, Sonia
dc.contributor.authorMosquera Rey, Alejandro
dc.contributor.authorRodríguez, Montserrat
dc.contributor.authorBlanco García, Francisco J
dc.contributor.authorFernández-Sueiro, José Luis
dc.contributor.authorGosálvez, Jaime
dc.contributor.authorFernández, José Luis
dc.date.accessioned2026-09-22T06:41:57Z
dc.date.available2026-09-22T06:41:57Z
dc.date.issued2014-04-24
dc.descriptionClinical trial
dc.description.abstract[Abstract] Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.
dc.description.sponsorshipThis study was supported by a grant from the Fondo de Investigaciones Sanitarias (FIS) PI11/01796.
dc.identifier.citationTamayo M, Pértega S, Mosquera A, Rodríguez M, Blanco FJ, Fernández-Sueiro JL, Gosálvez J, Fernández JL. Individual telomere length decay in patients with spondyloarthritis. Mutat Res. 2014 Jul;765:1-5.
dc.identifier.doi10.1016/J.MRFMMM.2014.04.006
dc.identifier.issn0921-8262
dc.identifier.urihttps://hdl.handle.net/2183/49354
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PI11%2F01796/ES/Determinación de la evolución de la longitud se las secuencias de ADN telomérico en leucocitos de pacientes con espondiloartritis (espondilitis anquilosante y artritis psoriásica), como marcador de actividad y progresión de la enfermedad, y de respuesta a/
dc.relation.urihttps://doi.org/10.1016/J.MRFMMM.2014.04.006
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAnkylosing spondylitis
dc.subjectPsoriasis
dc.subjectPsoriatic arthritis
dc.subjectTelomere length
dc.subjectqPCR
dc.titleIndividual Telomere Length Decay in Patients With Spondyloarthritis
dc.typejournal article
dc.type.hasVersionAM
dspace.entity.typePublication
relation.isAuthorOfPublication81bb68c9-ac97-4c16-987d-9469586d17ee
relation.isAuthorOfPublicationf357279a-035a-4279-a553-99cfd79bd2bb
relation.isAuthorOfPublication.latestForDiscovery81bb68c9-ac97-4c16-987d-9469586d17ee

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