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https://hdl.handle.net/2183/49354

Individual Telomere Length Decay in Patients With Spondyloarthritis

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URI: https://hdl.handle.net/2183/49354
DOI: 10.1016/J.MRFMMM.2014.04.006

Publication date

2014-04-24

Authors

Tamayo, María
Mosquera Rey, Alejandro
Rodríguez, Montserrat
Fernández-Sueiro, José Luis
Gosálvez, Jaime
Fernández, José Luis

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Tamayo M, Pértega S, Mosquera A, Rodríguez M, Blanco FJ, Fernández-Sueiro JL, Gosálvez J, Fernández JL. Individual telomere length decay in patients with spondyloarthritis. Mutat Res. 2014 Jul;765:1-5.

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Abstract

[Abstract] Telomere length was sequentially determined in peripheral blood leukocytes (PBL) from patients with ankylosing spondylitis (AS; n = 44) and psoriatic arthritis (PsA; n = 42) followed through 2.93 ± 0.99 years, using a quantitative PCR (qPCR) assay. The initial telomere size from PsA patients was higher than those with cutaneous psoriasis only (n = 53), possibly due to the inflammatory condition. The qPCR assay was sensitive enough to evidence a significant telomere length shortening in PBL from practically all subjects and PsA patients showed a higher rate of loss of telomere sequence than patients with AS during the follow-up time.

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Clinical trial

Keywords

Ankylosing spondylitis Psoriasis Psoriatic arthritis Telomere length qPCR

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https://doi.org/10.1016/J.MRFMMM.2014.04.006

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Attribution-NonCommercial-NoDerivatives 4.0 International

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Attribution-NonCommercial-NoDerivatives 4.0 International

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