Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

Abada, Sabah; Lecointre, Alexandre; Elhabiri, Mourad; Esteban-Gómez, David; Platas-Iglesias, Carlos; Tallec, Gaylord; Mazzanti, Marinella; Charbonnière, Loïc J.

Use this link to cite:

http://hdl.handle.net/2183/21354

Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing

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EstebanGomez_David_2012_Highly_relaxing_gadolinium_based_MRI_contrast_agents_responsive_Mg2+_sensing.pdf (683.84 KB)

Identifiers

URI: http://hdl.handle.net/2183/21354

Publication date

2012-04-28

Authors

Abada, Sabah

Lecointre, Alexandre

Elhabiri, Mourad

Esteban-Gómez, David

Platas-Iglesias, Carlos

Tallec, Gaylord

Mazzanti, Marinella

Charbonnière, Loïc J.

Bibliographic citation

Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing. S. Abada, A. Lecointre, M. Elhabiri, D. Esteban-Gómez, C. Platas-Iglesias, G. Tallec, M. Mazzanti and L. J. Charbonnière, Chem. Commun., 2012, 48, 4085–4087.

Abstract

[Abstract] A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (logKEuL = 25.7), a high relaxivity (8.5 mM−1 s−1 at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg2+, opening interesting perspectives for the design of cation responsive contrast agents.