Identification of Regulatory Mechanisms Driving Acquired Resistance to Olaparib in Ovarian Cancer

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UDC.coleccionInvestigación
UDC.conferenceTitleEACR 2026
UDC.departamentoCiencias da Computación e Tecnoloxías da Información
UDC.grupoInvLaboratorio de Aprendizaxe Automático en Ciencias Vivas (MALL)
UDC.institutoCentroCITIC - Centro de Investigación de Tecnoloxías da Información e da Comunicación
dc.contributor.authorAlonso-Pozo, Alicia
dc.contributor.authorFernández-Lozano, Carlos
dc.contributor.authorLiñares Blanco, José
dc.date.accessioned2026-09-04T09:07:02Z
dc.date.available2026-09-04T09:07:02Z
dc.date.issued2026
dc.descriptionAbstract do poster presentado en: Annual Congress of the European Association for Cancer Research (EACR 2026): Innovative Cancer Science, 8-11 June 2026, Budapest, Hungary. Abstracts do congreso en: https://febs.onlinelibrary.wiley.com/doi/epdf/10.1002/1878-0261.70318. Póster dispoñible en: https://hdl.handle.net/2183/49160.
dc.description.abstract[Abstract]: This study reconstructs single-cell differentiation trajectories and infers transcription factor activity in high-grade serous ovarian cancer to identify key regulatory mechanisms driving the transition from olaparib-sensitive to resistant cellular states.
dc.description.sponsorshipRePo–SUDOE, with project reference S1/1.1/P0033, a project co–financed by the Interreg Sudoe Programme through the European Regional Development Fund (ERDF). J.L.B. is supported by the Galician Government through the fellowship ED481B_072. Grant PID2024–162441OA–I00 funded by MICIU/AEI/ 10.13039/501100011033 and by “ERDF/EU”.
dc.description.sponsorshipXunta de Galicia; ED481B_072
dc.description.sponsorshipInterreg Sudoe; S1/1.1/P0033
dc.identifier.citationA. Alonso-Pozo, C. Fernández-Lozano, and J. Liñares-Blanco, "Identification of Regulatory Mechanisms Driving Acquired Resistance to Olaparib in Ovarian Cancer", Abstract EACR26-1361, Molecular Oncology 20 (Suppl. 1), August 2026, ISSN 1878-0261, https://doi.org/10.1002/1878-0261.70318
dc.identifier.doi10.1002/1878-0261.70318
dc.identifier.issn1878-0261
dc.identifier.issn1574-7891
dc.identifier.urihttps://hdl.handle.net/2183/49155
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.hasversionA. Alonso-Pozo, C. Fernández-Lozano, and J. Liñares-Blanco, "Identification of Regulatory Mechanisms Driving Acquired Resistance to Olaparib in Ovarian Cancer" [Poster], Annual Congress of the European Association for Cancer Research (EACR 2026): Innovative Cancer Science, 8-11 June 2026, Budapest, Hungary. https://hdl.handle.net/2183/49160.
dc.relation.projectIDinfo:eu-repo/grantAgreement//Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-162441OA-I00/ES/REDES NEURONALES CONVOLUCIONALES DE GRAFOS EXPLICABLES PARA LA INNOVACION EN ONCOLOGIA DE PRECISION Y RESISTENCIA A MEDICAMENTOS EN CANCER
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOvarian cancer
dc.subjectOlaparib resistance
dc.subjectTranscription factors
dc.titleIdentification of Regulatory Mechanisms Driving Acquired Resistance to Olaparib in Ovarian Cancer
dc.typeconference output
dspace.entity.typePublication
relation.isAuthorOfPublicatione5ddd06a-3e7f-4bf4-9f37-5f1cf3d3430a
relation.isAuthorOfPublicationcf4ecc37-12be-45fc-add3-01c6a7f02630
relation.isAuthorOfPublication.latestForDiscoverye5ddd06a-3e7f-4bf4-9f37-5f1cf3d3430a

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