Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, via electrophilic fluorination of lithiated bis-lactim ethers

Ruiz, María; Ojea, Vicente; Quintela López, José María; Guillín, Juan José

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http://hdl.handle.net/2183/442

Stereoselective synthesis of alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, via electrophilic fluorination of lithiated bis-lactim ethers

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Identifiers

URI: http://hdl.handle.net/2183/442

DOI: 10.1039/B204093J

Publication date

2002-06-25

Authors

Ruiz, María

Ojea, Vicente

Quintela López, José María

Guillín, Juan José

Bibliographic citation

Ruiz, M.; Ojea, V.; Quintela, J. M.; Guillín, J. J. Chem. Commun. 2002, 1600-1601

Abstract

[Abstract] Electrophilic fluorinations of lithiated bis-lactim ethers derived from cyclo-[L-AP4-D-Val] allow a direct access to alpha-monofluorinated phosphonate mimetics of naturally occurring phosphoserine and phosphothreonine, in enantiomerically pure form and suitable protected for solid-phase peptide synthesis.