Strategies to combat multidrug-resistant and persistent infectious diseases

Simple item page
UDC.coleccionInvestigaciónes_ES
UDC.departamentoFisioterapia, Medicina e Ciencias Biomédicases_ES
UDC.grupoInvInvestigación en Microbiología (INIBIC)es_ES
UDC.institutoCentroINIBIC - Instituto de Investigacións Biomédicas de A Coruñaes_ES
UDC.issue2es_ES
UDC.journalTitleAntibioticses_ES
UDC.startPage65es_ES
UDC.volume9es_ES
dc.contributor.authorPacios Santamaría, Olga
dc.contributor.authorBlasco, Lucía
dc.contributor.authorBleriot Rial, Inés
dc.contributor.authorFernández-García, Laura
dc.contributor.authorGonzález-Bardanca, Mónica
dc.contributor.authorAmbroa, Antón
dc.contributor.authorLópez Díaz, María
dc.contributor.authorBou, Germán
dc.contributor.authorTomás, María
dc.date.accessioned2025-02-20T10:58:01Z
dc.date.available2025-02-20T10:58:01Z
dc.date.issued2020-02-06
dc.descriptionReviewes_ES
dc.description.abstract[Abstract] Antibiotic failure is one of the most worrying health problems worldwide. We are currently facing an international crisis with several problematic facets: new antibiotics are no longer being discovered, resistance mechanisms are occurring in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria are hampering the successful treatment of infections. In this context, new anti-infectious strategies against multidrug-resistant (MDR) and persistent bacteria, as well as the rescue of Food and Drug Administration (FDA)-approved compounds (drug repurposing), are being explored. Among the highlighted new anti-infectious strategies, in this review, we focus on antimicrobial peptides, anti-virulence compounds, phage therapy, and new molecules. As drugs that are being repurposed, we highlight anti-inflammatory compounds, anti-psychotics, anti-helminthics, anti-cancerous drugs, and statins.es_ES
dc.description.sponsorshipThis study was funded by grants PI16/01163 and PI19/00878 awarded to M. Tomás within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development, and Innovation 2008–2011) and co-financed by the ISCIII-Deputy General Directorate for Evaluation and Promotion of Research—European Regional Development Fund “A way of Making Europe” and Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI, RD16/0016/0006), as well as by the Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC, http://www.seimc.org/). R. Trastoy and L. Fernández-García were financially supported by grants from the SEIMC and the Deputación Provincial da Coruña (Xunta de Galicia), respectively.es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F01163/ES/"Terapia FÁGICA CLÍNICA: Nuevos retos"es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F00878/ES/"TRATAMIENTOS ANTI-TOLERANCIA Y/O ANTI-PERSISTENCIA BACTERIANA: CLAVES PARA LA LUCHA FRENTE A BACTERIAS RESISTENTES"es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreemenr/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RD16%2F0016%2F0006/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN PATOLOGÍAS INFECCIOSASes_ES
dc.identifier.citationPacios O, Blasco L, Bleriot I, Fernandez-Garcia L, González Bardanca M, Ambroa A, López M, Bou G, Tomás M. Strategies to combat multidrug-resistant and persistent infectious diseases. Antibiotics (Basel). 2020 Feb 6;9(2):65.es_ES
dc.identifier.doi10.3390/antibiotics9020065
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/2183/41225
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/antibiotics9020065es_ES
dc.rightsCreative Commons Attribution 4.0 International License (CC-BY 4.0)es_ES
dc.rights.accessRightsopen accesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectAnti-MDR strategieses_ES
dc.subjectAnti-persistent treatmentses_ES
dc.subjectDrug repurposinges_ES
dc.titleStrategies to combat multidrug-resistant and persistent infectious diseaseses_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
relation.isAuthorOfPublication909e08d1-6ed1-4b99-9e9e-c64eb72e7dea
relation.isAuthorOfPublication.latestForDiscovery909e08d1-6ed1-4b99-9e9e-c64eb72e7dea

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Pacios_Strategies_2020.pdf
Size:
662.53 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Investigación (FFISIO)