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http://hdl.handle.net/2183/41225 Strategies to combat multidrug-resistant and persistent infectious diseases
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Authors
Pacios Santamaría, Olga
Blasco, Lucía
Bleriot Rial, Inés
Fernández-García, Laura
González-Bardanca, Mónica
Ambroa, Antón
López Díaz, María
Tomás, María
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Bibliographic citation
Pacios O, Blasco L, Bleriot I, Fernandez-Garcia L, González Bardanca M, Ambroa A, López M, Bou G, Tomás M. Strategies to combat multidrug-resistant and persistent infectious diseases. Antibiotics (Basel). 2020 Feb 6;9(2):65.
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Abstract
[Abstract] Antibiotic failure is one of the most worrying health problems worldwide. We are currently facing an international crisis with several problematic facets: new antibiotics are no longer being discovered, resistance mechanisms are occurring in almost all clinical isolates of bacteria, and recurrent infections caused by persistent bacteria are hampering the successful treatment of infections. In this context, new anti-infectious strategies against multidrug-resistant (MDR) and persistent bacteria, as well as the rescue of Food and Drug Administration (FDA)-approved compounds (drug repurposing), are being explored. Among the highlighted new anti-infectious strategies, in this review, we focus on antimicrobial peptides, anti-virulence compounds, phage therapy, and new molecules. As drugs that are being repurposed, we highlight anti-inflammatory compounds, anti-psychotics, anti-helminthics, anti-cancerous drugs, and statins.
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Creative Commons Attribution 4.0 International License (CC-BY 4.0)
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Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International License (CC-BY 4.0)