Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes

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UDC.coleccionInvestigaciónes_ES
UDC.departamentoQuímicaes_ES
UDC.endPage4118es_ES
UDC.grupoInvReactividade Química e Fotorreactividade (REACT!)es_ES
UDC.issue28es_ES
UDC.journalTitleChemical Communicationses_ES
UDC.startPage4115es_ES
UDC.volume55es_ES
dc.contributor.authorPujales-Paradela, Rosa
dc.contributor.authorSavic, Tanja
dc.contributor.authorBrandariz, Isabel
dc.contributor.authorPérez-Lourido, Paulo
dc.contributor.authorAngelovski, Goran
dc.contributor.authorEsteban-Gómez, David
dc.contributor.authorPlatas-Iglesias, Carlos
dc.date.accessioned2022-03-18T09:23:10Z
dc.date.available2022-03-18T09:23:10Z
dc.date.issued2019-03-11
dc.description.abstract[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni²⁺ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in ¹⁹F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.es_ES
dc.description.sponsorshipAuthors R. P.-P., D. E.-G. and C. P.-I. thank Ministerio de Economía y Competitividad (CTQ2016-76756-P) and Xunta de Galicia (ED431B 2017/59 and ED431D 2017/01) for generous financial support. R. P.-P. thanks Ministerio de Economía y Competitividad for a PhD FPI grant (BES-2014-068399) and a fellowship for a short term stay in Tuebingen (EEBB-I-17-12213). T. S. thanks the German Academic Exchange Service (DAAD) for the PhD fellowshipes_ES
dc.description.sponsorshipXunta de Galicia; ED431B 2017/59es_ES
dc.description.sponsorshipXunta de Galicia; ED431D 2017/01es_ES
dc.identifier.citationR. Pujales-Paradela, T. Savić, I. Brandariz, P. Pérez-Lourido, G. Angelovski, D. Esteban-Gómez and C. Platas-Iglesias, Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes, Chem. Commun., 2019, 55, 4115–4118. DOI: 10.1039/C9CC01204Des_ES
dc.identifier.doi10.1039/C9CC01204D
dc.identifier.issn1364-548X
dc.identifier.urihttp://hdl.handle.net/2183/30055
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-76756-P/ES/NUEVA GENERACION DE AGENTES DE CONTRASTE PARA IMAGEN POR RESONANCIA MAGNETICA (IRM) ALTERNATIVOS A LOS DERIVADOS DE GADOLINIO/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BES-2014-068399/ES/
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/EEBB-I-17-12213/ES/
dc.relation.urihttps://doi.org/10.1039/C9CC01204Des_ES
dc.rights.accessRightsopen accesses_ES
dc.titleReinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probeses_ES
dc.typejournal articlees_ES
dspace.entity.typePublication
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