Use this link to cite:
http://hdl.handle.net/2183/30055 Reinforced Ni(ɪɪ)-Cyclam Derivatives as Dual ¹H/¹⁹F MRI Probes
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Savic, Tanja
Pérez-Lourido, Paulo
Angelovski, Goran
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R. Pujales-Paradela, T. Savić, I. Brandariz, P. Pérez-Lourido, G. Angelovski, D. Esteban-Gómez and C. Platas-Iglesias, Reinforced Ni(II)-cyclam derivatives as dual 1H/19F MRI probes, Chem. Commun., 2019, 55, 4115–4118. DOI: 10.1039/C9CC01204D
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Abstract
[Abstract] Reinforced cross-bridged Ni²⁺-cyclam complexes were functionalised with pendant arms containing both amide protons and CF₃ groups that lead to a dual ¹H/¹⁹F response. The resulting complexes possess very high inertness favourable for MRI applications. The paramagnetism of the Ni²⁺ ion shifts the amide resonance 56 ppm away from bulk water favouring the chemical exchange saturation transfer (CEST) effect and shortening the acquisition times in ¹⁹F magnetic resonance imaging (MRI) experiments, thus enhancing the signal-to-noise ratios compared to the fluorinated diamagnetic reference.